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Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling

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@article{3d004086a3944e2b9ec6bbb1099255d2,
title = "Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling",
abstract = "Background: Motor-related brain activity in Parkinson's disease has been investigated in a multitude of functional neuroimaging studies, which often yielded apparently conflicting results. Our previous meta-analysis did not resolve inconsistencies regarding cortical activation differences in Parkinson's disease, which might be related to the limited number of studies that could be included. Therefore, we conducted a revised meta-analysis including a larger number of studies. The objectives of this study were to elucidate brain areas that consistently show abnormal motor-related activation in Parkinson's disease and to reveal their functional connectivity profiles using meta-analytic approaches. Methods: We applied a quantitative meta-analysis of functional neuroimaging studies testing limb movements in Parkinson's disease comprising data from 39 studies, of which 15 studies (285 of 571 individual patients) were published after the previous meta-analysis. We also conducted meta-analytic connectivity modeling to elucidate the connectivity profiles of areas showing abnormal activation. Results: We found consistent motor-related underactivation of bilateral posterior putamen and cerebellum in Parkinson's disease. Primary motor cortex and the supplementary motor area also showed deficient activation, whereas cortical regions localized directly anterior to these areas expressed overactivation. Connectivity modeling revealed that areas showing decreased activation shared a common pathway through the posterior putamen, whereas areas showing increased activation were connected to the anterior putamen. Conclusions: Despite conflicting results in individual neuroimaging studies, this revised meta-analytic approach identified consistent patterns of abnormal motor-related activation in Parkinson's disease. The distinct patterns of decreased and increased activity might be determined by their connectivity with different subregions of the putamen.",
keywords = "Parkinson's disease, functional neuroimaging, meta-analysis, motor, Parkinson Disease/diagnostic imaging, Brain/diagnostic imaging, Magnetic Resonance Imaging, Functional Neuroimaging, Humans, Neural Pathways/diagnostic imaging",
author = "Herz, {Damian M} and David Meder and Camilleri, {Julia A} and Eickhoff, {Simon B} and Siebner, {Hartwig R}",
note = "{\textcopyright} 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.",
year = "2021",
month = may,
doi = "10.1002/mds.28468",
language = "English",
volume = "36",
pages = "1180--1190",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Brain Motor Network Changes in Parkinson's Disease

T2 - Evidence from Meta-Analytic Modeling

AU - Herz, Damian M

AU - Meder, David

AU - Camilleri, Julia A

AU - Eickhoff, Simon B

AU - Siebner, Hartwig R

N1 - © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

PY - 2021/5

Y1 - 2021/5

N2 - Background: Motor-related brain activity in Parkinson's disease has been investigated in a multitude of functional neuroimaging studies, which often yielded apparently conflicting results. Our previous meta-analysis did not resolve inconsistencies regarding cortical activation differences in Parkinson's disease, which might be related to the limited number of studies that could be included. Therefore, we conducted a revised meta-analysis including a larger number of studies. The objectives of this study were to elucidate brain areas that consistently show abnormal motor-related activation in Parkinson's disease and to reveal their functional connectivity profiles using meta-analytic approaches. Methods: We applied a quantitative meta-analysis of functional neuroimaging studies testing limb movements in Parkinson's disease comprising data from 39 studies, of which 15 studies (285 of 571 individual patients) were published after the previous meta-analysis. We also conducted meta-analytic connectivity modeling to elucidate the connectivity profiles of areas showing abnormal activation. Results: We found consistent motor-related underactivation of bilateral posterior putamen and cerebellum in Parkinson's disease. Primary motor cortex and the supplementary motor area also showed deficient activation, whereas cortical regions localized directly anterior to these areas expressed overactivation. Connectivity modeling revealed that areas showing decreased activation shared a common pathway through the posterior putamen, whereas areas showing increased activation were connected to the anterior putamen. Conclusions: Despite conflicting results in individual neuroimaging studies, this revised meta-analytic approach identified consistent patterns of abnormal motor-related activation in Parkinson's disease. The distinct patterns of decreased and increased activity might be determined by their connectivity with different subregions of the putamen.

AB - Background: Motor-related brain activity in Parkinson's disease has been investigated in a multitude of functional neuroimaging studies, which often yielded apparently conflicting results. Our previous meta-analysis did not resolve inconsistencies regarding cortical activation differences in Parkinson's disease, which might be related to the limited number of studies that could be included. Therefore, we conducted a revised meta-analysis including a larger number of studies. The objectives of this study were to elucidate brain areas that consistently show abnormal motor-related activation in Parkinson's disease and to reveal their functional connectivity profiles using meta-analytic approaches. Methods: We applied a quantitative meta-analysis of functional neuroimaging studies testing limb movements in Parkinson's disease comprising data from 39 studies, of which 15 studies (285 of 571 individual patients) were published after the previous meta-analysis. We also conducted meta-analytic connectivity modeling to elucidate the connectivity profiles of areas showing abnormal activation. Results: We found consistent motor-related underactivation of bilateral posterior putamen and cerebellum in Parkinson's disease. Primary motor cortex and the supplementary motor area also showed deficient activation, whereas cortical regions localized directly anterior to these areas expressed overactivation. Connectivity modeling revealed that areas showing decreased activation shared a common pathway through the posterior putamen, whereas areas showing increased activation were connected to the anterior putamen. Conclusions: Despite conflicting results in individual neuroimaging studies, this revised meta-analytic approach identified consistent patterns of abnormal motor-related activation in Parkinson's disease. The distinct patterns of decreased and increased activity might be determined by their connectivity with different subregions of the putamen.

KW - Parkinson's disease

KW - functional neuroimaging

KW - meta-analysis

KW - motor

KW - Parkinson Disease/diagnostic imaging

KW - Brain/diagnostic imaging

KW - Magnetic Resonance Imaging

KW - Functional Neuroimaging

KW - Humans

KW - Neural Pathways/diagnostic imaging

UR - http://www.scopus.com/inward/record.url?scp=85099080749&partnerID=8YFLogxK

U2 - 10.1002/mds.28468

DO - 10.1002/mds.28468

M3 - Journal article

C2 - 33427336

VL - 36

SP - 1180

EP - 1190

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 5

M1 - 28468

ER -

ID: 61730809