Brain capillary pericytes and neurovascular coupling

Søren Grubb; Martin Lauritzen; Christian Aalkjær

doi:10.1016/j.cbpa.2020.110893

Brain capillary pericytes and neurovascular coupling

Søren Grubb, Martin Lauritzen, Christian Aalkjær

Afdeling for Hjerne- og Nerveundersøgelser

28 Citationer (Scopus)

Abstract

The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells, that determine the the diameter of the blood vessels and consequently the flow. Here we discuss the structure of these blood vessels and the excitationcontraction coupling of the mural cells.

Originalsprog	Engelsk
Tidsskrift	Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
Vol/bind	254
Sider (fra-til)	110893
ISSN	1095-6433
DOI	https://doi.org/10.1016/j.cbpa.2020.110893
Status	Udgivet - apr. 2021

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10.1016/j.cbpa.2020.110893

Citationsformater

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AB - The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells, that determine the the diameter of the blood vessels and consequently the flow. Here we discuss the structure of these blood vessels and the excitationcontraction coupling of the mural cells.

KW - Arterioles smooth muscle neuron astrocyte sphincter

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DO - 10.1016/j.cbpa.2020.110893

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SN - 1095-6433

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JO - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

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ER -

Brain capillary pericytes and neurovascular coupling

Abstract

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