Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T

Carl-Johan Boraxbekk; Anna Lind Hansen; Esben Thade Petersen; Hartwig R. Siebner; Anouk Marsman

Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T

Carl-Johan Boraxbekk, Anna Lind Hansen, Esben Thade Petersen, Hartwig R. Siebner, Anouk Marsman

Abstract

Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.

Originalsprog	Engelsk
Titel	Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Antal sider	1
Forlag	The International Society for Magnetic Resonance in Medicine
Publikationsdato	2020
Sider	1-1
Artikelnummer	1853
Status	Udgivet - 2020
Begivenhed	ISMRM & SMRT Virtual Conference & Exhibition 2020 - Virtual conference Varighed: 8 aug. 2020 → 14 aug. 2020 https://www.ismrm.org/20m/

Konference

Konference	ISMRM & SMRT Virtual Conference & Exhibition 2020
Lokation	Virtual conference
Periode	08/08/2020 → 14/08/2020
Internetadresse	https://www.ismrm.org/20m/

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https://archive.ismrm.org/2020/1853.html

Citationsformater

Boraxbekk, C.-J., Hansen, A. L., Petersen, E. T., Siebner, H. R., & Marsman, A. (2020). Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T. I Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition (s. 1-1). Artikel 1853 The International Society for Magnetic Resonance in Medicine. https://archive.ismrm.org/2020/1853.html

Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T. / Boraxbekk, Carl-Johan; Hansen, Anna Lind; Petersen, Esben Thade et al.
Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition. The International Society for Magnetic Resonance in Medicine, 2020. s. 1-1 1853.

Publikation: Bidrag til bog/antologi/rapport › Konferenceabstrakt i proceedings › Forskning › peer review

Boraxbekk, C-J, Hansen, AL, Petersen, ET , Siebner, HR & Marsman, A 2020, Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T. i Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition., 1853, The International Society for Magnetic Resonance in Medicine, s. 1-1, ISMRM & SMRT Virtual Conference & Exhibition 2020, 08/08/2020. <https://archive.ismrm.org/2020/1853.html>

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abstract = "Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.",

author = "Carl-Johan Boraxbekk and Hansen, {Anna Lind} and Petersen, {Esben Thade} and Siebner, {Hartwig R.} and Anouk Marsman",

year = "2020",

language = "English",

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booktitle = "Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition",

publisher = "The International Society for Magnetic Resonance in Medicine",

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TY - ABST

T1 - Brain and immune system crosstalk

T2 - ISMRM & SMRT Virtual Conference & Exhibition 2020

AU - Boraxbekk, Carl-Johan

AU - Hansen, Anna Lind

AU - Petersen, Esben Thade

AU - Siebner, Hartwig R.

AU - Marsman, Anouk

PY - 2020

Y1 - 2020

N2 - Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.

AB - Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.

M3 - Conference abstract in proceedings

SP - 1

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BT - Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition

PB - The International Society for Magnetic Resonance in Medicine

Y2 - 8 August 2020 through 14 August 2020

ER -

Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T

Abstract

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