Bovine Colostrum to Children With Short Bowel Syndrome: A Randomized, Double-Blind, Crossover Pilot Study

Lise Aunsholt, Palle Bekker Jeppesen, Pernille Lund, Per Torp Sangild, Inge Bøtker Rasmussen Ifaoui, Niels Qvist, Steffen Husby

    29 Citationer (Scopus)

    Abstract

    Background: Management of short bowel syndrome (SBS) aims to achieve intestinal autonomy to prevent fluid, electrolyte, and nutrient deficiencies and maintain adequate development. Remnant intestinal adaptation is required to obtain autonomy. In the newborn pig, colostrum has been shown to support intestinal development and hence adaptive processes. Aim: The efficacy of bovine colostrum to improve intestinal function in children with SBS was evaluated by metabolic balance studies. Materials and Methods: Nine children with SBS were included in a randomized, double-blind, crossover study. Twenty percent of enteral fluid intake was replaced with bovine colostrum or a mixed milk diet for 4 weeks, separated by a 4-week washout period. Intestinal absorption of energy and wet weight was used to assess intestinal function and the efficacy of colostrum. Results: Colostrum did not improve energy or wet weight absorption compared with the mixed milk diet (P = 1.00 and P = .93, respectively). Growth as measured by weight and knemometry did not differ between diets (P = .93 and P = .28). In these patients,
    OriginalsprogEngelsk
    TidsskriftJournal of Parenteral and Enteral Nutrition
    Vol/bind38
    Udgave nummer1
    Sider (fra-til)99-106
    ISSN0148-6071
    DOI
    StatusUdgivet - 2014

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