@article{bbe57cfcda3b4b459172ffe5cafdcaa6,
title = "Bortezomib, melphalan, prednisone (VMP) versus melphalan, prednisone, thalidomide (MPT) in elderly newly diagnosed multiple myeloma patients: A retrospective case-matched study",
abstract = "Novel agents in combination with melphalan and prednisone (MP) significantly improved progression-free survival (PFS) and overall survival (OS) in multiple myeloma (MM). Randomized trials comparing MP plus bortezomib (VMP) versus MP plus thalidomide (MPT) are lacking. Nine hundred and fifty-six elderly (>65 years) newly diagnosed MM patients from six European randomized trials were retrospectively analyzed and matched for age, albumin, and beta2-microglobulin at diagnosis, 296 patients were selected from the VMP groups, and 294 from MPT. Complete response rate was 21% in the VMP patients and 13% in the MPT patients (P = 0.007). After a median follow-up of 34 months (range, 1-92), VMP significantly prolonged both PFS (median 32.5 vs. 22.9 months, HR 0.65; 95% CI 0.52-0.82; P < 0.001) and OS (median 79.7 vs. 45.1 months, HR 0.44; 95% CI 0.32-0.59; P < 0.001) in comparison with MPT. The benefit in terms of OS of the VMP group was quite similar among patients with different risk factors defined by sex, ISS, ECOG performance status, or serum creatinine but not among patients ≥ 75 years. Multivariate analysis confirmed that VMP was an independent predictor of longer PFS and OS. In a control-case matched analysis, PFS and OS were prolonged in patients who received VMP in comparison with those treated with MPT.",
keywords = "Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Boronic Acids, Case-Control Studies, Disease-Free Survival, Drug Evaluation, Female, Hematologic Diseases, Humans, Kaplan-Meier Estimate, Male, Melphalan, Multiple Myeloma, Nervous System Diseases, Prednisone, Prognosis, Proportional Hazards Models, Pyrazines, Randomized Controlled Trials as Topic, Retrospective Studies, Thalidomide, Treatment Outcome",
author = "Fortunato Morabito and Sara Bringhen and Alessandra Larocca and Pierre Wijermans and {Victoria Mateos}, Maria and Peter Gimsing and Carla Mazzone and Daniela Gottardi and Paola Omed{\`e} and Sonja Zweegman and {Jos{\'e} Lahuerta}, Juan and Renato Zambello and Pellegrino Musto and Valeria Magarotto and Martijn Schaafsma and Albert Oriol and Gunnar Juliusson and Chiara Cerrato and Lucio Catalano and Massimo Gentile and {Isabel Turel}, Ana and {Marina Liberati}, Anna and Maide Cavalli and Davide Rossi and Roberto Passera and Stefano Rosso and Meral Beksac and Michele Cavo and Anders Waage and {San Miguel}, Jesus and Mario Boccadoro and Pieter Sonneveld and Antonio Palumbo and Massimo Offidani",
note = "Copyright {\textcopyright} 2013 Wiley Periodicals, Inc.",
year = "2014",
month = apr,
doi = "10.1002/ajh.23641",
language = "English",
volume = "89",
pages = "355--62",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "4",
}