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Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes

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@article{1a024afbf6df4f0c8ba37dfa6c12669f,
title = "Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes",
abstract = "Background and aim: In rodents, osteocalcin (OCN) stimulates insulin production and insulin sensitivity, both important factors during partial remission in humans with type 1 diabetes (T1D). However, decreased OCN has been reported in both adult and pediatric T1D. This study aims at investigating bone turnover and partial remission in children and adolescents with recent onset T1D. Subjects and methods: Ninety-nine individuals (33{\%} girls) were recruited within 3 months of T1D onset and examined three times, 6 months apart. Outcome variables were bone formation markers OCN and procollagen type 1 amino-terminal propeptide (P1NP) and the bone resorption marker C-terminal crosslinked telopeptide of type 1 collagen (CTX). Dependent variables included IDAA1c (surrogate marker of partial remission), total body bone mineral density (BMD) and stimulated C-peptide as representative of endogenous insulin production. Results: OCN- and P1NP Z-scores were significantly decreased throughout the study, whereas CTX Z-scores were increased. None of the bone turnover markers changed significantly between visits. Total body BMD Z-score did not change during the study but was significantly higher than the reference population at visit 2 (P =.035). There were no differences in the bone turnover markers for those in partial remission as defined by either C-peptide or IDAA1c at any visit. The individual change in CTX Z-score was negatively associated with the increase of IDAA1c (P =.030) independent of C-peptide decline (P =.034). Conclusion: Bone turnover markers indicate increased bone resorption and decreased bone formation during the first year of T1D. The negative association between bone resorption and IDAA1c might represent compensatory mechanisms affecting insulin sensitivity.",
keywords = "bone density, bone remodeling, C-peptide, diabetes mellitus, type 1, osteocalcin",
author = "Madsen, {Jens Otto Broby} and Herskin, {Camilla Winther} and Bo Zerahn and Jensen, {Andreas Kryger} and J{\o}rgensen, {Niklas Rye} and Olsen, {Birthe Susanne} and Jannet Svensson and Flemming Pociot and Jesper Johannesen",
note = "{\circledC} 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2020",
month = "3",
doi = "10.1111/pedi.12963",
language = "English",
volume = "21",
pages = "366--376",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Wiley",
number = "2",

}

RIS

TY - JOUR

T1 - Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes

AU - Madsen, Jens Otto Broby

AU - Herskin, Camilla Winther

AU - Zerahn, Bo

AU - Jensen, Andreas Kryger

AU - Jørgensen, Niklas Rye

AU - Olsen, Birthe Susanne

AU - Svensson, Jannet

AU - Pociot, Flemming

AU - Johannesen, Jesper

N1 - © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2020/3

Y1 - 2020/3

N2 - Background and aim: In rodents, osteocalcin (OCN) stimulates insulin production and insulin sensitivity, both important factors during partial remission in humans with type 1 diabetes (T1D). However, decreased OCN has been reported in both adult and pediatric T1D. This study aims at investigating bone turnover and partial remission in children and adolescents with recent onset T1D. Subjects and methods: Ninety-nine individuals (33% girls) were recruited within 3 months of T1D onset and examined three times, 6 months apart. Outcome variables were bone formation markers OCN and procollagen type 1 amino-terminal propeptide (P1NP) and the bone resorption marker C-terminal crosslinked telopeptide of type 1 collagen (CTX). Dependent variables included IDAA1c (surrogate marker of partial remission), total body bone mineral density (BMD) and stimulated C-peptide as representative of endogenous insulin production. Results: OCN- and P1NP Z-scores were significantly decreased throughout the study, whereas CTX Z-scores were increased. None of the bone turnover markers changed significantly between visits. Total body BMD Z-score did not change during the study but was significantly higher than the reference population at visit 2 (P =.035). There were no differences in the bone turnover markers for those in partial remission as defined by either C-peptide or IDAA1c at any visit. The individual change in CTX Z-score was negatively associated with the increase of IDAA1c (P =.030) independent of C-peptide decline (P =.034). Conclusion: Bone turnover markers indicate increased bone resorption and decreased bone formation during the first year of T1D. The negative association between bone resorption and IDAA1c might represent compensatory mechanisms affecting insulin sensitivity.

AB - Background and aim: In rodents, osteocalcin (OCN) stimulates insulin production and insulin sensitivity, both important factors during partial remission in humans with type 1 diabetes (T1D). However, decreased OCN has been reported in both adult and pediatric T1D. This study aims at investigating bone turnover and partial remission in children and adolescents with recent onset T1D. Subjects and methods: Ninety-nine individuals (33% girls) were recruited within 3 months of T1D onset and examined three times, 6 months apart. Outcome variables were bone formation markers OCN and procollagen type 1 amino-terminal propeptide (P1NP) and the bone resorption marker C-terminal crosslinked telopeptide of type 1 collagen (CTX). Dependent variables included IDAA1c (surrogate marker of partial remission), total body bone mineral density (BMD) and stimulated C-peptide as representative of endogenous insulin production. Results: OCN- and P1NP Z-scores were significantly decreased throughout the study, whereas CTX Z-scores were increased. None of the bone turnover markers changed significantly between visits. Total body BMD Z-score did not change during the study but was significantly higher than the reference population at visit 2 (P =.035). There were no differences in the bone turnover markers for those in partial remission as defined by either C-peptide or IDAA1c at any visit. The individual change in CTX Z-score was negatively associated with the increase of IDAA1c (P =.030) independent of C-peptide decline (P =.034). Conclusion: Bone turnover markers indicate increased bone resorption and decreased bone formation during the first year of T1D. The negative association between bone resorption and IDAA1c might represent compensatory mechanisms affecting insulin sensitivity.

KW - bone density

KW - bone remodeling

KW - C-peptide

KW - diabetes mellitus, type 1

KW - osteocalcin

U2 - 10.1111/pedi.12963

DO - 10.1111/pedi.12963

M3 - Journal article

VL - 21

SP - 366

EP - 376

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

IS - 2

ER -

ID: 58635893