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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes

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DOI

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BACKGROUND AND AIM: In rodents, Osteocalcin (OCN) stimulate insulin production and insulin sensitivity, both important factors during partial remission in humans with type 1 diabetes (T1D). However, decreased OCN has reported in both adult and pediatric T1D. This study aims at investigating bone turnover and partial remission in children and adolescents with recent onset T1D.

SUBJECTS AND METHODS: 99 individuals (33% girls) were recruited within 3 months of T1D onset and examined three times, 6 months apart. Outcome variables were bone formation markers OCN and procollagen type-1 amino-terminal propeptide (P1NP) and the bone resorption marker C-terminal cross-linked telopeptide of type-1 collagen (CTX). Dependent variables included IDAA1c (surrogate marker of partial remission), total-body bone mineral density (BMD) and stimulated C-peptide as representative of endogenous insulin production.

RESULTS: OCN- and P1NP Z-scores were significantly decreased throughout the study, whereas CTX Z-scores were increased. None of the bone turnover markers changed significantly between visits. Total body BMD Z-score did not change during the study but was significantly higher than the reference population at visit 2 (P=0.035). There were no differences in the bone turnover markers for those in partial remission as defined by either C-peptide or IDAA1c at any visit. The individual change in CTX Z-score was negatively associated with the increase of IDAA1c (P=0.030) independent of C-peptide decline (P=0.034).

CONCLUSION: Bone turnover markers indicate increased bone resorption and decreased bone formation during the first year of T1D. The negative association between bone resorption and IDAA1c might represent compensatory mechanisms affecting insulin sensitivity. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftPediatric Diabetes
ISSN1399-543X
DOI
StatusE-pub ahead of print - 15 dec. 2019

Bibliografisk note

This article is protected by copyright. All rights reserved.

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