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BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. BloodSpot: a database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Ensembl Genomes 2013: scaling up access to genome-wide data

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. BloodSpot: a database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Research on human and murine haematopoiesis has resulted in a vast number of gene-expression data sets that can potentially answer questions regarding normal and aberrant blood formation. To researchers and clinicians with limited bioinformatics experience, these data have remained available, yet largely inaccessible. Current databases provide information about gene-expression but fail to answer key questions regarding co-regulation, genetic programs or effect on patient survival. To address these shortcomings, we present BloodSpot (www.bloodspot.eu), which includes and greatly extends our previously released database HemaExplorer, a database of gene expression profiles from FACS sorted healthy and malignant haematopoietic cells. A revised interactive interface simultaneously provides a plot of gene expression along with a Kaplan-Meier analysis and a hierarchical tree depicting the relationship between different cell types in the database. The database now includes 23 high-quality curated data sets relevant to normal and malignant blood formation and, in addition, we have assembled and built a unique integrated data set, BloodPool. Bloodpool contains more than 2000 samples assembled from six independent studies on acute myeloid leukemia. Furthermore, we have devised a robust sample integration procedure that allows for sensitive comparison of user-supplied patient samples in a well-defined haematopoietic cellular space.

OriginalsprogEngelsk
TidsskriftNucleic Acids Research
Vol/bind44
Udgave nummerD1
Sider (fra-til)D917-D924
ISSN0305-1048
DOI
StatusUdgivet - 2016

ID: 45783627