Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma

Pär I Johansson; Nis A Windeløv; Lars S Rasmussen; Anne Marie Sørensen; Sisse R Ostrowski

doi:10.4103/0974-2700.115327

Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma

Pär I Johansson, Nis A Windeløv, Lars S Rasmussen, Anne Marie Sørensen, Sisse R Ostrowski

59 Citationer (Scopus)

Abstract

Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to the injury that involves the neurohumoral, inflammatory and hemostatic systems.

Originalsprog	Engelsk
Tidsskrift	Journal of Emergencies, Trauma and Shock
Vol/bind	6
Udgave nummer	3
Sider (fra-til)	171-5
Antal sider	5
ISSN	0974-2700
DOI	https://doi.org/10.4103/0974-2700.115327
Status	Udgivet - jul. 2013

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10.4103/0974-2700.115327

Citationsformater

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title = "Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma",

abstract = "Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to the injury that involves the neurohumoral, inflammatory and hemostatic systems.",

author = "Johansson, {P{\"a}r I} and Windel{\o}v, {Nis A} and Rasmussen, {Lars S} and S{\o}rensen, {Anne Marie} and Ostrowski, {Sisse R}",

year = "2013",

month = jul,

doi = "10.4103/0974-2700.115327",

language = "English",

volume = "6",

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journal = "Journal of Emergencies, Trauma and Shock",

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TY - JOUR

T1 - Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma

AU - Johansson, Pär I

AU - Windeløv, Nis A

AU - Rasmussen, Lars S

AU - Sørensen, Anne Marie

AU - Ostrowski, Sisse R

PY - 2013/7

Y1 - 2013/7

N2 - Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to the injury that involves the neurohumoral, inflammatory and hemostatic systems.

AB - Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to the injury that involves the neurohumoral, inflammatory and hemostatic systems.

U2 - 10.4103/0974-2700.115327

DO - 10.4103/0974-2700.115327

M3 - Journal article

C2 - 23960372

SN - 0974-2700

VL - 6

SP - 171

EP - 175

JO - Journal of Emergencies, Trauma and Shock

JF - Journal of Emergencies, Trauma and Shock

IS - 3

ER -

Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma

Abstract

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