Blood-brain barrier permeability of L-dopa in man

M L Friis; O B Paulson; M M Hertz; T G Bolwig

doi:10.1111/j.1365-2362.1981.tb01845.x

Blood-brain barrier permeability of L-dopa in man

M L Friis, O B Paulson, M M Hertz, T G Bolwig

6 Citationer (Scopus)

Abstract

The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.

Originalsprog	Engelsk
Tidsskrift	European Journal of Clinical Investigation
Vol/bind	11
Udgave nummer	3
Sider (fra-til)	231-4
Antal sider	4
ISSN	0014-2972
DOI	https://doi.org/10.1111/j.1365-2362.1981.tb01845.x
Status	Udgivet - jun. 1981
Udgivet eksternt	Ja

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10.1111/j.1365-2362.1981.tb01845.x

Citationsformater

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title = "Blood-brain barrier permeability of L-dopa in man",

abstract = "The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.",

keywords = "Adult, Aged, Blood-Brain Barrier, Capillary Permeability, Carbidopa/pharmacology, Carbon Radioisotopes, Cerebrovascular Circulation, Female, Humans, Levodopa/metabolism, Male, Middle Aged, Radioisotope Dilution Technique",

author = "Friis, {M L} and Paulson, {O B} and Hertz, {M M} and Bolwig, {T G}",

year = "1981",

month = jun,

doi = "10.1111/j.1365-2362.1981.tb01845.x",

language = "English",

volume = "11",

pages = "231--4",

journal = "European Journal of Clinical Investigation",

issn = "0014-2972",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Blood-brain barrier permeability of L-dopa in man

AU - Friis, M L

AU - Paulson, O B

AU - Hertz, M M

AU - Bolwig, T G

PY - 1981/6

Y1 - 1981/6

N2 - The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.

AB - The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.

KW - Adult

KW - Aged

KW - Blood-Brain Barrier

KW - Capillary Permeability

KW - Carbidopa/pharmacology

KW - Carbon Radioisotopes

KW - Cerebrovascular Circulation

KW - Female

KW - Humans

KW - Levodopa/metabolism

KW - Male

KW - Middle Aged

KW - Radioisotope Dilution Technique

U2 - 10.1111/j.1365-2362.1981.tb01845.x

DO - 10.1111/j.1365-2362.1981.tb01845.x

M3 - Journal article

C2 - 6791943

SN - 0014-2972

VL - 11

SP - 231

EP - 234

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 3

ER -

Blood-brain barrier permeability of L-dopa in man

Abstract

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