Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Bleeding and thrombosis in intensive care patients with thrombocytopenia-Protocol for a topical systematic review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Delirium assessment in neuro-critically ill patients: A validation study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Rebound pain following peripheral nerve block anaesthesia in acute ankle fracture surgery: An exploratory pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Association between perioperative hyperoxia and cerebrovascular complications after laparotomy-A post-hoc follow-up study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Dexmedetomidine for the management of delirium in critically ill patients-A protocol for a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

BACKGROUND: Thrombocytopenia is a common condition in critically ill patients in the intensive care unit (ICU). It is associated with prolonged stay in the ICU, increased transfusion requirements, risk of bleeding and mortality. The evidence regarding the use of prophylactic platelet transfusion and thrombosis prophylaxis in patients with thrombocytopenia in the ICU is unknown. To direct future research, we aim to assess the current evidence regarding prophylactic platelet transfusion and thrombosis prophylaxis on patient-important benefits and harms in the ICU population.

METHODS: We will conduct a topical systematic review of all study designs (ie no study design will per se be excluded from the proposed review) in accordance with the Preferred Reporting Items for Systematic and Meta-Analyses (PRISMA) statements. We will include studies on adult patients in the ICU where the incidence of thrombocytopenia and the predefined outcome measures, including mortality, quality-of-life, thrombotic events and haemorrhagic events are reported. We will provide descriptive analyses of the included studies/trials, ie no meta-analyses will be conducted, and the quality of evidence will be assessed according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

CONCLUSION: The outlined topical systematic review will provide important data on the benefits and harms of prophylactic platelet transfusion and thrombosis prophylaxis in ICU patients with thrombocytopenia and provide estimates on the rate of thrombocytopenia in this vulnerable population.

OriginalsprogEngelsk
TidsskriftActa Anaesthesiologica Scandinavica
Vol/bind63
Udgave nummer2
Sider (fra-til)270-273
Antal sider4
ISSN0001-5172
DOI
StatusUdgivet - feb. 2019

ID: 56228118