Bladder contractility is modulated by Kv7 channels in pig detrusor

Julie Svalø; Michala Bille; Neeraja Parameswaran Theepakaran; Majid Sheykhzade; Jørgen Nordling; Pierre Bouchelouche

doi:10.1016/j.ejphar.2013.05.005

Bladder contractility is modulated by Kv7 channels in pig detrusor

Julie Svalø, Michala Bille, Neeraja Parameswaran Theepakaran, Majid Sheykhzade, Jørgen Nordling, Pierre Bouchelouche

Urinvejssygdomme

26 Citationer (Scopus)

Abstract

Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome. We have therefore used myography to examine the function of Kv7 channels in detrusor, i.e. pig bladder, with a view to determining the effects of the following potassium channel activators: ML213 (Kv7.2/Kv7.4 channels) and retigabine (Kv7.2-7.5 channels). Retigabine produced a concentration-dependent relaxation of carbachol- and electric field-induced contractions. The potency was similar in magnitude to that of ML213-induced relaxation, suggesting that Kv7.2 and/or Kv7.4 channels constitute the subtypes that are relevant to bladder contractility. The effects of retigabine and ML213 were attenuated by pre-incubation with 10µM XE991 (Kv7.1-7.5 channel blocker) (P

Originalsprog	Engelsk
Tidsskrift	European Journal of Clinical Pharmacology
Vol/bind	715
Udgave nummer	1-3
Sider (fra-til)	312-20
Antal sider	9
ISSN	0031-6970
DOI	https://doi.org/10.1016/j.ejphar.2013.05.005
Status	Udgivet - 5 sep. 2013

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10.1016/j.ejphar.2013.05.005

Citationsformater

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title = "Bladder contractility is modulated by Kv7 channels in pig detrusor",

abstract = "Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome. We have therefore used myography to examine the function of Kv7 channels in detrusor, i.e. pig bladder, with a view to determining the effects of the following potassium channel activators: ML213 (Kv7.2/Kv7.4 channels) and retigabine (Kv7.2-7.5 channels). Retigabine produced a concentration-dependent relaxation of carbachol- and electric field-induced contractions. The potency was similar in magnitude to that of ML213-induced relaxation, suggesting that Kv7.2 and/or Kv7.4 channels constitute the subtypes that are relevant to bladder contractility. The effects of retigabine and ML213 were attenuated by pre-incubation with 10µM XE991 (Kv7.1-7.5 channel blocker) (P",

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T1 - Bladder contractility is modulated by Kv7 channels in pig detrusor

AU - Svalø, Julie

AU - Bille, Michala

AU - Parameswaran Theepakaran, Neeraja

AU - Sheykhzade, Majid

AU - Nordling, Jørgen

AU - Bouchelouche, Pierre

PY - 2013/9/5

Y1 - 2013/9/5

N2 - Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome. We have therefore used myography to examine the function of Kv7 channels in detrusor, i.e. pig bladder, with a view to determining the effects of the following potassium channel activators: ML213 (Kv7.2/Kv7.4 channels) and retigabine (Kv7.2-7.5 channels). Retigabine produced a concentration-dependent relaxation of carbachol- and electric field-induced contractions. The potency was similar in magnitude to that of ML213-induced relaxation, suggesting that Kv7.2 and/or Kv7.4 channels constitute the subtypes that are relevant to bladder contractility. The effects of retigabine and ML213 were attenuated by pre-incubation with 10µM XE991 (Kv7.1-7.5 channel blocker) (P

AB - Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome. We have therefore used myography to examine the function of Kv7 channels in detrusor, i.e. pig bladder, with a view to determining the effects of the following potassium channel activators: ML213 (Kv7.2/Kv7.4 channels) and retigabine (Kv7.2-7.5 channels). Retigabine produced a concentration-dependent relaxation of carbachol- and electric field-induced contractions. The potency was similar in magnitude to that of ML213-induced relaxation, suggesting that Kv7.2 and/or Kv7.4 channels constitute the subtypes that are relevant to bladder contractility. The effects of retigabine and ML213 were attenuated by pre-incubation with 10µM XE991 (Kv7.1-7.5 channel blocker) (P

U2 - 10.1016/j.ejphar.2013.05.005

DO - 10.1016/j.ejphar.2013.05.005

M3 - Journal article

C2 - 23707187

SN - 0031-6970

VL - 715

SP - 312

EP - 320

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 1-3

ER -

Bladder contractility is modulated by Kv7 channels in pig detrusor

Abstract

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