Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Biomarkers in tumors of the central nervous system - a review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Early IL-2 treatment of mice with Pseudomonas aeruginosa pneumonia induced PMN-dominating response and reduced lung pathology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A case of false-positive pneumococcal urinary antigen test in a bacteremic Streptococcus agalactiae infection

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. Nephrotic syndrome and pulmonary hypertension as complications of intravenous drug abuse

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Oral symptoms and pathologies in Danish patients with chronic kidney disease- a pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The molecular profile of mucosal melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mitotic and Proliferative Indices in WHO Grade III Meningioma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Corticotroph aggressive pituitary tumours and carcinomas frequently harbour ATRX mutations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pharmacokinetic analysis of [68Ga]Ga-DOTA-TOC PET in meningiomas for assessment of in vivo somatostatin receptor subtype 2

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Until recently, diagnostics of brain tumors were almost solely based on morphology and immunohistochemical stainings for relatively unspecific lineage markers. Although certain molecular markers have been known for longer than a decade (combined loss of chromosome 1p and 19q in oligodendrogliomas), molecular biomarkers were not included in the WHO scheme until 2016. Now, the classification of diffuse gliomas rests on an integration of morphology and molecular results. Also, for many other central nervous system tumor entities, specific diagnostic, prognostic and predictive biomarkers have been detected and continue to emerge. Previously, we considered brain tumors with similar histology to represent a single disease entity. We now realize that histologically identical tumors might show alterations in different molecular pathways, and often represent separate diseases with different natural history and response to treatment. Hence, knowledge about specific biomarkers is of great importance for individualized treatment and follow-up. In this paper we review the biomarkers that we currently use in the diagnostic work-up of brain tumors.

OriginalsprogEngelsk
TidsskriftAPMIS - Journal of Pathology, Microbiology and Immunology
Vol/bind127
Udgave nummer5
Sider (fra-til)265-287
Antal sider23
ISSN0903-4641
DOI
StatusUdgivet - maj 2019

Bibliografisk note

© 2019 APMIS. Published by John Wiley & Sons Ltd.

ID: 58939612