Biomarkers in dementia disorders - a narrative review

Steen Gregers Hasselbalch

doi:10.61409/A09240634

Biomarkers in dementia disorders - a narrative review

Steen Gregers Hasselbalch^*

^*Corresponding author af dette arbejde

Afdeling for Hjerne- og Nervesygdomme NEU

Abstract

With the introduction of specific or unspecific biomarkers, the diagnosis of dementia disorders has changed from a purely clinical to a biological construct. This review presents biomarkers for the most common neurodegenerative disorders. Specific biomarkers for misfolded proteins have been developed for Alzheimer's disease and dementia with Lewy bodies. Unspecific biomarkers for neurodegeneration, synaptic dysfunction and neuroinflammation may also be helpful in diagnosing or staging dementia disorders.

Originalsprog	Engelsk
Artikelnummer	A09240634
Tidsskrift	Danish Medical Bulletin
Vol/bind	72
Udgave nummer	3
ISSN	0907-8916
DOI	https://doi.org/10.61409/A09240634
Status	Udgivet - 21 feb. 2025

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10.61409/A09240634Licens: CC BY-NC-ND

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abstract = "With the introduction of specific or unspecific biomarkers, the diagnosis of dementia disorders has changed from a purely clinical to a biological construct. This review presents biomarkers for the most common neurodegenerative disorders. Specific biomarkers for misfolded proteins have been developed for Alzheimer's disease and dementia with Lewy bodies. Unspecific biomarkers for neurodegeneration, synaptic dysfunction and neuroinflammation may also be helpful in diagnosing or staging dementia disorders.",

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AB - With the introduction of specific or unspecific biomarkers, the diagnosis of dementia disorders has changed from a purely clinical to a biological construct. This review presents biomarkers for the most common neurodegenerative disorders. Specific biomarkers for misfolded proteins have been developed for Alzheimer's disease and dementia with Lewy bodies. Unspecific biomarkers for neurodegeneration, synaptic dysfunction and neuroinflammation may also be helpful in diagnosing or staging dementia disorders.

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KW - Biomarkers/blood

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KW - Alzheimer Disease/diagnosis

KW - Lewy Body Disease/diagnosis

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Biomarkers in dementia disorders - a narrative review

Abstract

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