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Biological and small molecule strategies in migraine therapy with relation to the calcitonin gene-related peptide family of peptides

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@article{a5432ee68a064bde8ed37d7d3442d6f7,
title = "Biological and small molecule strategies in migraine therapy with relation to the calcitonin gene-related peptide family of peptides",
abstract = "Migraine is one of the most common of neurological disorders with a global prevalence of up to 15%. One in five migraineurs have frequent episodic or chronic migraine requiring prophylactic treatment. In recent years, specific pharmacological treatments targeting calcitonin gene-related peptide (CGRP) signalling molecules have provided safe and effective treatments, monoclonal antibodies for prophylaxis and gepants for acute therapy. Albeit beneficial, it is important to understand the molecular mechanisms of these new drugs to better understand migraine pathophysiology and improve therapy. Here, we describe current views on the role of the CGRP family of peptides - CGRP, calcitonin, adrenomedullin, amylin - and their receptors in the trigeminovascular system. All these molecules are present within the trigeminovascular system but differ in expression and localization. It is likely that they have different roles, which can be utilized in providing additional drug targets.",
keywords = "adrenomedullin, amylin, calcitonin, CGRP, CLR, RAMPs, receptors",
author = "Lars Edvinsson and Edvinsson, {Jacob C A} and Haanes, {Kristian A}",
note = "This article is protected by copyright. All rights reserved.",
year = "2021",
month = aug,
day = "19",
doi = "10.1111/bph.15669",
language = "English",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "John/Wiley & Sons Ltd",

}

RIS

TY - JOUR

T1 - Biological and small molecule strategies in migraine therapy with relation to the calcitonin gene-related peptide family of peptides

AU - Edvinsson, Lars

AU - Edvinsson, Jacob C A

AU - Haanes, Kristian A

N1 - This article is protected by copyright. All rights reserved.

PY - 2021/8/19

Y1 - 2021/8/19

N2 - Migraine is one of the most common of neurological disorders with a global prevalence of up to 15%. One in five migraineurs have frequent episodic or chronic migraine requiring prophylactic treatment. In recent years, specific pharmacological treatments targeting calcitonin gene-related peptide (CGRP) signalling molecules have provided safe and effective treatments, monoclonal antibodies for prophylaxis and gepants for acute therapy. Albeit beneficial, it is important to understand the molecular mechanisms of these new drugs to better understand migraine pathophysiology and improve therapy. Here, we describe current views on the role of the CGRP family of peptides - CGRP, calcitonin, adrenomedullin, amylin - and their receptors in the trigeminovascular system. All these molecules are present within the trigeminovascular system but differ in expression and localization. It is likely that they have different roles, which can be utilized in providing additional drug targets.

AB - Migraine is one of the most common of neurological disorders with a global prevalence of up to 15%. One in five migraineurs have frequent episodic or chronic migraine requiring prophylactic treatment. In recent years, specific pharmacological treatments targeting calcitonin gene-related peptide (CGRP) signalling molecules have provided safe and effective treatments, monoclonal antibodies for prophylaxis and gepants for acute therapy. Albeit beneficial, it is important to understand the molecular mechanisms of these new drugs to better understand migraine pathophysiology and improve therapy. Here, we describe current views on the role of the CGRP family of peptides - CGRP, calcitonin, adrenomedullin, amylin - and their receptors in the trigeminovascular system. All these molecules are present within the trigeminovascular system but differ in expression and localization. It is likely that they have different roles, which can be utilized in providing additional drug targets.

KW - adrenomedullin

KW - amylin

KW - calcitonin

KW - CGRP

KW - CLR

KW - RAMPs

KW - receptors

U2 - 10.1111/bph.15669

DO - 10.1111/bph.15669

M3 - Review

C2 - 34411289

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

ER -

ID: 67198162