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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Biological and environmental predictors of heterogeneity in neurocognitive ageing: Evidence from Betula and other longitudinal studies

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  • Lars Nyberg
  • Carl-Johan Boraxbekk
  • Daniel Eriksson Sörman
  • Patrik Hansson
  • Agneta Herlitz
  • Karolina Kauppi
  • Jessica K Ljungberg
  • Hugo Lövheim
  • Anders Lundquist
  • Annelie Nordin Adolfsson
  • Anna Oudin
  • Sara Pudas
  • Michael Rönnlund
  • Mikael Stiernstedt
  • Anna Sundström
  • Rolf Adolfsson
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Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in aging by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive aging. We discuss the vital importance of sampling, analytic methods, consideration of non-ignorable dropout, and related issues for valid conclusions on factors that influence healthy neurocognitive aging.

OriginalsprogEngelsk
TidsskriftAgeing Research Reviews
Sider (fra-til)101184
ISSN1568-1637
DOI
StatusE-pub ahead of print - 26 sep. 2020

Bibliografisk note

Copyright © 2020. Published by Elsevier B.V.

ID: 60942553