Bias due to withdrawal in long-term randomised trials in COPD: evidence from the TORCH study

Jørgen Vestbo; Julie Anne Anderson; Peter Mark Anthony Calverley; Bartolomé Celli; Gary Thomas Ferguson; Christine Jenkins; Julie Carol Yates; Paul Wyatt Jones

doi:10.1111/j.1752-699X.2010.00198.x

Bias due to withdrawal in long-term randomised trials in COPD: evidence from the TORCH study

Jørgen Vestbo, Julie Anne Anderson, Peter Mark Anthony Calverley, Bartolomé Celli, Gary Thomas Ferguson, Christine Jenkins, Julie Carol Yates, Paul Wyatt Jones

75 Citationer (Scopus)

Abstract

Randomised controlled trials (RCTs) are considered the least biased method for evaluating drug efficacy and several large long-term RCTs in chronic obstructive pulmonary disease have been published. These usually include drugs with symptomatic benefits and have significant withdrawal rates.

Originalsprog	Engelsk
Tidsskrift	Clinical Respiratory Journal
Vol/bind	5
Udgave nummer	1
Sider (fra-til)	44-9
Antal sider	6
ISSN	1752-6981
DOI	https://doi.org/10.1111/j.1752-699X.2010.00198.x
Status	Udgivet - 2011

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title = "Bias due to withdrawal in long-term randomised trials in COPD: evidence from the TORCH study",

abstract = "Randomised controlled trials (RCTs) are considered the least biased method for evaluating drug efficacy and several large long-term RCTs in chronic obstructive pulmonary disease have been published. These usually include drugs with symptomatic benefits and have significant withdrawal rates.",

keywords = "Albuterol, Androstadienes, Bias (Epidemiology), Bronchodilator Agents, Drug Combinations, Humans, Observation, Patient Dropouts, Placebos, Proportional Hazards Models, Pulmonary Disease, Chronic Obstructive, Randomized Controlled Trials as Topic",

author = "J{\o}rgen Vestbo and Anderson, \{Julie Anne\} and Calverley, \{Peter Mark Anthony\} and Bartolom{\'e} Celli and Ferguson, \{Gary Thomas\} and Christine Jenkins and Yates, \{Julie Carol\} and Jones, \{Paul Wyatt\}",

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T2 - evidence from the TORCH study

AU - Vestbo, Jørgen

AU - Anderson, Julie Anne

AU - Calverley, Peter Mark Anthony

AU - Celli, Bartolomé

AU - Ferguson, Gary Thomas

AU - Jenkins, Christine

AU - Yates, Julie Carol

AU - Jones, Paul Wyatt

PY - 2011

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AB - Randomised controlled trials (RCTs) are considered the least biased method for evaluating drug efficacy and several large long-term RCTs in chronic obstructive pulmonary disease have been published. These usually include drugs with symptomatic benefits and have significant withdrawal rates.

KW - Albuterol

KW - Androstadienes

KW - Bias (Epidemiology)

KW - Bronchodilator Agents

KW - Drug Combinations

KW - Humans

KW - Observation

KW - Patient Dropouts

KW - Placebos

KW - Proportional Hazards Models

KW - Pulmonary Disease, Chronic Obstructive

KW - Randomized Controlled Trials as Topic

UR - https://www.scopus.com/pages/publications/78650278281

U2 - 10.1111/j.1752-699X.2010.00198.x

DO - 10.1111/j.1752-699X.2010.00198.x

M3 - Journal article

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SN - 1752-6981

VL - 5

SP - 44

EP - 49

JO - Clinical Respiratory Journal

JF - Clinical Respiratory Journal

IS - 1

ER -

Bias due to withdrawal in long-term randomised trials in COPD: evidence from the TORCH study

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