beta-Arrestin 1 and 2 stabilize the angiotensin II type I receptor in distinct high-affinity conformations

S J Sanni, J T Hansen, M M Bonde, T Speerschneider, G L Christensen, S Munk, S Gammeltoft, J L Hansen

23 Citationer (Scopus)

Abstract

The angiotensin II type 1 (AT(1)) receptor belongs to family A of 7 transmembrane (7TM) receptors. The receptor has important roles in the cardiovascular system and is commonly used as a drug target in cardiovascular diseases. Interaction of 7TM receptors with G proteins or beta-arrestins often induces higher binding affinity for agonists. Here, we examined interactions between AT(1A) receptors and beta-arrestins to look for differences between the AT(1A) receptor interaction with beta-arrestin1 and beta-arrestin2.
OriginalsprogEngelsk
TidsskriftBritish Journal of Pharmacology
Vol/bind161
Udgave nummer1
Sider (fra-til)150-61
Antal sider12
ISSN0007-1188
DOI
StatusUdgivet - 1 sep. 2010

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