TY - JOUR
T1 - Beta-adrenergic effects on cerebral circulation
AU - Olesen, J
PY - 1986
Y1 - 1986
N2 - Noradrenaline, adrenaline, and isoprenaline were infused intracarotidly and the regional cerebral blood flow measured with the intracarotid injection-stationary detector method in patients undergoing carotid angiography. No effect was seen, and beta blockade with intracarotid propranolol also had no effect. The adrenergic effects on cerebral blood vessels are probably neurogenic, and circulating adrenergic agonists and antagonists are unlikely to play a role. Pertubations of adrenergic substances in blood are therefore unlikely to be important in migraine pathophysiology.
AB - Noradrenaline, adrenaline, and isoprenaline were infused intracarotidly and the regional cerebral blood flow measured with the intracarotid injection-stationary detector method in patients undergoing carotid angiography. No effect was seen, and beta blockade with intracarotid propranolol also had no effect. The adrenergic effects on cerebral blood vessels are probably neurogenic, and circulating adrenergic agonists and antagonists are unlikely to play a role. Pertubations of adrenergic substances in blood are therefore unlikely to be important in migraine pathophysiology.
KW - Adrenergic beta-Antagonists/therapeutic use
KW - Blood-Brain Barrier/drug effects
KW - Carbon Dioxide/blood
KW - Cerebrovascular Circulation/drug effects
KW - Humans
KW - Migraine Disorders/drug therapy
KW - Oxygen/blood
KW - Propranolol/therapeutic use
KW - Vascular Resistance/drug effects
U2 - 10.1177/03331024860060S505
DO - 10.1177/03331024860060S505
M3 - Journal article
C2 - 2879631
SN - 0333-1024
VL - 6 Suppl 5
SP - 41
EP - 46
JO - Cephalalgia : an international journal of headache
JF - Cephalalgia : an international journal of headache
ER -