TY - JOUR
T1 - Baseline and Exercise Predictors of VO2peak in Systolic Heart Failure Patients
T2 - Results from SMARTEX-HF
AU - Karlsen, Trine
AU - Videm, Vibeke
AU - Halle, Martin
AU - Ellingsen, Øyvind
AU - Støylen, Asbjørn
AU - Dalen, Håvard
AU - Delagardelle, Charles
AU - Larsen, Alf-Inge
AU - Hole, Torstein
AU - Mezzani, Alessandro
AU - Van Craenenbroeck, Emeline M
AU - Beckers, Paul
AU - Pressler, Axel
AU - Christle, Jeffrey W
AU - Winzer, Ephraim
AU - Mangner, Norman
AU - Woitek, Felix
AU - Höllriegel, Robert
AU - Snoer, Martin
AU - Feiereisen, Patrick
AU - Valborgland, Torstein
AU - Linke, Axel
AU - Prescott, Eva
PY - 2019/11/1
Y1 - 2019/11/1
N2 - PURPOSE: To investigate baseline, exercise testing, and exercise training-mediated predictors of change in peak oxygen uptake (VO2peak) from baseline to 12-week follow-up (ΔVO2peak) in a post-hoc analysis from the SMARTEX Heart Failure trial.METHODS: We studied 215 patients with heart failure with left ventricular ejection fraction (LVEF) <35%, and NYHA class II-III, who were randomized to either supervised high intensity interval training (HIIT) with exercise target intensity 90-95% of peak heart rate (HRpeak), supervised moderate continuous training (MCT) with target intensity 60-70% of HRpeak, or who received a recommendation of regular exercise on their own (RRE). Predictors of ΔVO2peak were assessed in two models; A logistic regression model comparing highest and lowest tertile (baseline parameters) and a multivariate linear regression model (test/training/clinical parameters).RESULTS: The change in VO2peak in response to the interventions (ΔVO2peak) varied substantially, from -8.50 to +11.30 mL·kg·min. Baseline NYHA (class II gave higher odds vs III, odds ratio (OR) 7.1 (2.0, 24.9), p=0.002), LVEF OR per % 1.1 (1.0, 1.2), p = 0.005), age (OR per 10 years 0.5 (0.3, 0.8)), p=0.003) were associated with ΔVO2peak.In the multivariate linear regression, 34% of the variability in [INCREMENT]VO2peak was explained by the increase in exercise training workload, [INCREMENT]HRpeak between baseline and 12-wk post-testing, age, and ever having smoked.CONCLUSION: Exercise training response (ΔVO2peak) correlated negatively with age, LVEF and NYHA class. The ability to increase workload during the training period, and increased ΔHRpeak between baseline and the 12-week test were associated with a positive outcome.
AB - PURPOSE: To investigate baseline, exercise testing, and exercise training-mediated predictors of change in peak oxygen uptake (VO2peak) from baseline to 12-week follow-up (ΔVO2peak) in a post-hoc analysis from the SMARTEX Heart Failure trial.METHODS: We studied 215 patients with heart failure with left ventricular ejection fraction (LVEF) <35%, and NYHA class II-III, who were randomized to either supervised high intensity interval training (HIIT) with exercise target intensity 90-95% of peak heart rate (HRpeak), supervised moderate continuous training (MCT) with target intensity 60-70% of HRpeak, or who received a recommendation of regular exercise on their own (RRE). Predictors of ΔVO2peak were assessed in two models; A logistic regression model comparing highest and lowest tertile (baseline parameters) and a multivariate linear regression model (test/training/clinical parameters).RESULTS: The change in VO2peak in response to the interventions (ΔVO2peak) varied substantially, from -8.50 to +11.30 mL·kg·min. Baseline NYHA (class II gave higher odds vs III, odds ratio (OR) 7.1 (2.0, 24.9), p=0.002), LVEF OR per % 1.1 (1.0, 1.2), p = 0.005), age (OR per 10 years 0.5 (0.3, 0.8)), p=0.003) were associated with ΔVO2peak.In the multivariate linear regression, 34% of the variability in [INCREMENT]VO2peak was explained by the increase in exercise training workload, [INCREMENT]HRpeak between baseline and 12-wk post-testing, age, and ever having smoked.CONCLUSION: Exercise training response (ΔVO2peak) correlated negatively with age, LVEF and NYHA class. The ability to increase workload during the training period, and increased ΔHRpeak between baseline and the 12-week test were associated with a positive outcome.
U2 - 10.1249/MSS.0000000000002193
DO - 10.1249/MSS.0000000000002193
M3 - Journal article
C2 - 31688648
SN - 0195-9131
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
ER -