Bambuterol: clinical effects of three doses of bambuterol once daily in asthmatic patients

Twenty‐two asthmatics received bambuterol solution, a terbutaline pro‐drug, once every evening. The following doses were each given orally for 7 days in a double‐blind crossover study: 0.185, 0.270 and 0.400 mg/kg. Bambuterol 0.270 mg/kg was preferable regarding clinical effects and side effects. The plasma concentration of generated terbutaline showed a slow linear decrease at all doses. Tests of two methods for objective measurements of tremor in five patients did not add any new data compared with the subjective recordings.