Bacterial invasion of the submicron osteocyte lacuna-canaliculi network (OLCN); a part of osteomyelitis disease biology

Louise Kruse Jensen*, Julie Birch, Henrik Elvang, Klaus Kirketerp, Hans Gottlieb

*Corresponding author af dette arbejde

Abstract

Two chronic osteomyelitis patients, a diabetic foot osteomyelitis patient and a fracture-related infection patient, all with staphylococci-positive microbiology, were examined to confirm the clinical relevance of bacterial invasion of the submicron osteocyte lacuna-canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry and light microscopy both Staphylococcus aureus and Staphylococcus epidermidis were identified within the OLCN of all four patients. The findings consolidate that bacterial OLCN invasion is a clinically relevant part of osteomyelitis disease biology, which from experimental porcine infections, seems to be time depending. The microscopy pictures of the four patients significantly add to visualize the phenomenon of bacterial OLCN invasion.

OriginalsprogEngelsk
TidsskriftAPMIS
Vol/bind131
Udgave nummer7
Sider (fra-til)325-332
Antal sider8
ISSN0903-4641
DOI
StatusUdgivet - jul. 2023

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