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Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis

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@article{486e976998644faebc941a80bc990c70,
title = "Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis",
abstract = "BACKGROUND: Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstrated by several authors indicating that biofilm not only is a key player in carcinogenesis, but also may contribute to the understanding of side-specific colon cancer-right sided colon cancer versus left sided. In this article, we briefly highlight the major findings of the research of biofilm and carcinogenesis and demonstrate our findings of colonic cancer tissue and colonic polyp examined for biofilm.CASE PRESENTATION: Colonic cancer tissue from a patient with a right-sided colon cancer, and an adenoma tubular polyp were examined for biofilm formation by flourescens in situ hybridization. In cancer tissue we found biofilm formation on the surface epithelium but surprisingly also deep into the crypts. No biofilms were found in tubular polyp tissue.CONCLUSIONS: To our knowledge, this is the first-time biofilm formation deep into colonic crypts are demonstrated in a patient with right-sided colon cancer. This may indicate that bacterial biofilm may have a key role in carcinogenesis.",
author = "Hans Raskov and Kragh, {Kasper N{\o}rskov} and Thomas Bjarnsholt and Mahdi Alamili and Ismail G{\"o}genur",
year = "2018",
month = "9",
day = "17",
doi = "10.1186/s40169-018-0209-2",
language = "English",
volume = "7",
pages = "30",
journal = "Clinical and Translational Medicine",
issn = "2001-1326",
publisher = "SpringerOpen",
number = "1",

}

RIS

TY - JOUR

T1 - Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis

AU - Raskov, Hans

AU - Kragh, Kasper Nørskov

AU - Bjarnsholt, Thomas

AU - Alamili, Mahdi

AU - Gögenur, Ismail

PY - 2018/9/17

Y1 - 2018/9/17

N2 - BACKGROUND: Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstrated by several authors indicating that biofilm not only is a key player in carcinogenesis, but also may contribute to the understanding of side-specific colon cancer-right sided colon cancer versus left sided. In this article, we briefly highlight the major findings of the research of biofilm and carcinogenesis and demonstrate our findings of colonic cancer tissue and colonic polyp examined for biofilm.CASE PRESENTATION: Colonic cancer tissue from a patient with a right-sided colon cancer, and an adenoma tubular polyp were examined for biofilm formation by flourescens in situ hybridization. In cancer tissue we found biofilm formation on the surface epithelium but surprisingly also deep into the crypts. No biofilms were found in tubular polyp tissue.CONCLUSIONS: To our knowledge, this is the first-time biofilm formation deep into colonic crypts are demonstrated in a patient with right-sided colon cancer. This may indicate that bacterial biofilm may have a key role in carcinogenesis.

AB - BACKGROUND: Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstrated by several authors indicating that biofilm not only is a key player in carcinogenesis, but also may contribute to the understanding of side-specific colon cancer-right sided colon cancer versus left sided. In this article, we briefly highlight the major findings of the research of biofilm and carcinogenesis and demonstrate our findings of colonic cancer tissue and colonic polyp examined for biofilm.CASE PRESENTATION: Colonic cancer tissue from a patient with a right-sided colon cancer, and an adenoma tubular polyp were examined for biofilm formation by flourescens in situ hybridization. In cancer tissue we found biofilm formation on the surface epithelium but surprisingly also deep into the crypts. No biofilms were found in tubular polyp tissue.CONCLUSIONS: To our knowledge, this is the first-time biofilm formation deep into colonic crypts are demonstrated in a patient with right-sided colon cancer. This may indicate that bacterial biofilm may have a key role in carcinogenesis.

U2 - 10.1186/s40169-018-0209-2

DO - 10.1186/s40169-018-0209-2

M3 - Journal article

VL - 7

SP - 30

JO - Clinical and Translational Medicine

JF - Clinical and Translational Medicine

SN - 2001-1326

IS - 1

ER -

ID: 55269155