Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Bacillus Calmette-Guérin immunotherapy for bladder cancer: A review of immunological aspects, clinical effects and BCG infections

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Bacteremia and urogenital infection with Actinomyces urogenitalis following prolonged urinary retention

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Two cases of tick-borne transmitted tularemia on Southern Zealand, Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Analysis of proximal bone margins in diabetic foot osteomyelitis by conventional culture, DNA sequencing and microscopy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. L-serine: a neglected amino acid with a potential therapeutic role in diabetes

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  5. Erythrocytes restrict microvesicle-induced production of reactive oxygen species by polymorphonuclear leukocytes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. How to Identify Common Variable Immunodeficiency Patients Earlier: General Practice Patterns

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Predictors for Pulmonary Tuberculosis Treatment Outcome in Denmark 2009-2014

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Primary health care: an opportunity for early identification of people living with undiagnosed HIV infection

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer has been used since 1976 when the first evidence of its ability to lower recurrence and progression-rates was published. Today, BCG immunotherapy is the choice of care for high grade non-muscle invasive bladder cancer (NMIBC) after transurethral resection. This article presents indications and procedure of BCG instillations, and outlines the effects on recurrence and progression of NMIBC. The BCG induced immunity in NMIBC is not yet fully understood. Animal studies point towards BCG inducing specific tumour immunity. We describe the current knowledge of how this immunity is induced, from internalization of BCG bacilli in urothelial cells, to cyto- and chemokine mediated recruitment of neutrophils, monocytes, macrophages, T cells, B cells and natural killer cells. In addition, we describe the process of trained immunity; the non-specific protective effects of BCG. Recent studies also indicate that dysbiosis of the urinary microbiome may cause lower urinary tract dysfunction. Side effects of BCG bladder instillations range from common, mild and transient symptoms, such as dysuria and flu-like symptoms, to more severe and rarely occurring life threatening complications. We review the literature and give an overview of reported incidences and management of BCG infections after intravesical instillation.

OriginalsprogEngelsk
TidsskriftAPMIS - Journal of Pathology, Microbiology and Immunology
ISSN0903-4641
DOI
StatusE-pub ahead of print - 2020

Bibliografisk note

© 2019 APMIS. Published by John Wiley & Sons Ltd.

ID: 58623032