Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Smallpox and BCG vaccination in childhood and cutaneous malignant melanoma in Danish adults followed from 18 to 49 years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Adverse pregnancy outcomes and infant mortality after quadrivalent HPV vaccination during pregnancy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Effectiveness of varying number of doses and timing between doses of quadrivalent HPV vaccine against severe cervical lesions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Ad hominem attacks on vaccine safety researchers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cesarean delivery and risk of atopic dermatitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Exercise training is associated with reduced pains from the musculoskeletal system in patients with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Copenhagen Baby Heart Study: a population study of newborns with prenatal inclusion

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The Bacille Calmette-Guérin (BCG) vaccine against tuberculosis (TB) may have beneficial non-specific effects (NSEs) beyond the protection against TB. This may be related to modifications of the innate immune system. We investigated the effect of BCG at birth on differential white blood cell (WBC) count in healthy, Danish infants.

METHOD: The Danish Calmette Study randomised newborns to BCG at birth (Danish strain 1331, Statens Serum Institut) or no intervention. A sub-group of infants had blood samples collected 4 days after randomisation (n = 161), and at age 3 months (n = 152) and 13 months (n = 300). We evaluated the effect of BCG on WBC differential count (total leucocytes, lymphocytes, monocytes, eosinophil, neutrophil and basophil granulocytes (109 cells/L)) measured in peripheral blood.

RESULTS: Overall, we found no effect of BCG on differential WBC counts at any time point.

CONCLUSION: BCG at birth did not affect WBC count in our cohort of healthy, Danish infants.

OriginalsprogEngelsk
TidsskriftVaccine
ISSN0264-410X
DOI
StatusUdgivet - 2020

Bibliografisk note

Copyright © 2020. Published by Elsevier Ltd.

ID: 59348088