Abstract
Immunosuppressive thiopurines like azathioprine, 6-mercaptopurine, and thioguanine are commonly used in inflammatory and neoplastic disorders. A subset of these patients are genetically slow metabolizers due to point-mutations in enzyme thiopurine S-methyltransferase (TPMT), and are at a higher risk of hematologic toxicity and leukemogenesis. We present such a patient who was a slow metabolizer for azathioprine, and developed a rapidly lethal form acute myeloid leukemia after relatively low dose exposure to the drug. There was prominent hemophagocytic activity in the bone marrow, and cytogenetic analysis showed a complex karyotype with monosomy 7, but no involvement of chromosome 8.
Originalsprog | Engelsk |
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Tidsskrift | American Journal of Hematology |
Vol/bind | 83 |
Udgave nummer | 1 |
Sider (fra-til) | 80-3 |
Antal sider | 4 |
ISSN | 0361-8609 |
DOI | |
Status | Udgivet - jan. 2008 |