TY - JOUR
T1 - Automatic semi-quantification of [(123)I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2
T2 - results from the ENC-DAT database
AU - Nobili, Flavio
AU - Naseri, Mehrdad
AU - De Carli, Fabrizio
AU - Asenbaum, Susan
AU - Booij, Jan
AU - Darcourt, Jacques
AU - Ell, Peter
AU - Kapucu, Ozlem
AU - Kemp, Paul
AU - Svarer, Claus
AU - Morbelli, Silvia
AU - Pagani, Marco
AU - Sabri, Osama
AU - Tatsch, Klaus
AU - Tossici-Bolt, Livia
AU - Sera, Terez
AU - Borght, Tierry Vander
AU - Van Laere, Koen
AU - Varrone, Andrea
PY - 2013
Y1 - 2013
N2 - PURPOSE: The aim of this study was to assess striatal dopamine transporter (DAT) availability in a large group of normal subjects. METHODS: The study included 122 healthy subjects, aged 18-83 years, recruited in the multicentre 'ENC-DAT' study (promoted by the European Association of Nuclear Medicine). Brain single photon emission computed tomography (SPECT) was acquired by means of dual-head cameras 3 h after [(123)I]FP-CIT administration. Specific to nondisplaceable binding ratios (SBRs) in the basal ganglia were computed using the 'BasGan' software, allowing automatic value extraction with partial volume effect correction. Multicentre camera inhomogeneity was taken into account by calibrating values on basal ganglia phantom data. SBR in each caudate nucleus (C) and putamen (P) were the dependent variables in a repeated measures general linear model analysis; age, gender, handedness and body mass index (BMI) were the independent variables. RESULTS: SBR values in C and P were significantly associated with age (mean rate decrease with age: 0.0306 per year, or 0.57 % of the general mean; p
AB - PURPOSE: The aim of this study was to assess striatal dopamine transporter (DAT) availability in a large group of normal subjects. METHODS: The study included 122 healthy subjects, aged 18-83 years, recruited in the multicentre 'ENC-DAT' study (promoted by the European Association of Nuclear Medicine). Brain single photon emission computed tomography (SPECT) was acquired by means of dual-head cameras 3 h after [(123)I]FP-CIT administration. Specific to nondisplaceable binding ratios (SBRs) in the basal ganglia were computed using the 'BasGan' software, allowing automatic value extraction with partial volume effect correction. Multicentre camera inhomogeneity was taken into account by calibrating values on basal ganglia phantom data. SBR in each caudate nucleus (C) and putamen (P) were the dependent variables in a repeated measures general linear model analysis; age, gender, handedness and body mass index (BMI) were the independent variables. RESULTS: SBR values in C and P were significantly associated with age (mean rate decrease with age: 0.0306 per year, or 0.57 % of the general mean; p
U2 - 10.1007/s00259-012-2304-8
DO - 10.1007/s00259-012-2304-8
M3 - Journal article
C2 - 23232506
SN - 1619-7070
VL - 40
SP - 564
EP - 573
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - 4
ER -