Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis

Spyridon Kontaxis*, Estela Laporta, Esther Garcia, Matteo Martinis, Letizia Leocani, Lucia Roselli, Mathias Due Buron, Ana Isabel Guerrero, Ana Zabala, Nicholas Cummins, Srinivasan Vairavan, Matthew Hotopf, Richard J B Dobson, Vaibhav A Narayan, Maria Libera La Porta, Gloria Dalla Costa, Melinda Magyari, Per Soelberg Sørensen, Carlos Nos, Raquel BailonGiancarlo Comi, On Behalf Of The Radar-Cns Consortium

*Corresponding author af dette arbejde
1 Citationer (Scopus)

Abstract

The aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). For 154 pwMS, MS-related clinical outcomes as well as the 2MWDs as evaluated by clinicians and derived from accelerometer data were collected from a total of 323 periodic clinical visits. Accelerometer data from a wearable device during 100 home-based 2MWD assessments were also acquired. The error in estimating the 2MWD was validated for walk tests performed at hospital, and then the correlation (r) between clinical outcomes and home-based 2MWD assessments was evaluated. Robust performance in estimating the 2MWD from the wearable device was obtained, yielding an error of less than 10% in about two-thirds of clinical visits. Correlation analysis showed that there is a strong association between the actual and the estimated 2MWD obtained either at hospital (r = 0.71) or at home (r = 0.58). Furthermore, the estimated 2MWD exhibits moderate-to-strong correlation with various MS-related clinical outcomes, including disability and fatigue severity scores. Automatic assessment of the 2MWD in pwMS is feasible with the usage of a consumer-friendly wearable device in clinical and non-clinical settings. Wearable devices can also enhance the assessment of MS-related clinical outcomes.

OriginalsprogEngelsk
Artikelnummer6017
TidsskriftSensors
Vol/bind23
Udgave nummer13
ISSN1424-3210
DOI
StatusUdgivet - 29 jun. 2023

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