Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study

Michael E Benros; Philip R Nielsen; Merete Nordentoft; William W Eaton; Susanne Oksbjerg Dalton; Preben Bo Mortensen

doi:10.1176/appi.ajp.2011.11030516

Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study

Michael E Benros, Philip R Nielsen, Merete Nordentoft, William W Eaton, Susanne Oksbjerg Dalton, Preben Bo Mortensen

454 Citationer (Scopus)

Abstract

Autoimmune diseases have been associated with an increased risk of schizophrenia. It has been suggested that brain-reactive autoantibodies are part of the mechanisms behind this association. Furthermore, an increased permeability of the blood-brain barrier has been observed during periods of infection and inflammation. The authors therefore investigated whether autoimmune diseases combined with exposures to severe infections may increase the risk of schizophrenia

Originalsprog	Engelsk
Tidsskrift	American Journal of Psychiatry
Vol/bind	168
Udgave nummer	12
Sider (fra-til)	1303-10
Antal sider	8
ISSN	0002-953X
DOI	https://doi.org/10.1176/appi.ajp.2011.11030516
Status	Udgivet - 2011

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10.1176/appi.ajp.2011.11030516

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title = "Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study",

abstract = "Autoimmune diseases have been associated with an increased risk of schizophrenia. It has been suggested that brain-reactive autoantibodies are part of the mechanisms behind this association. Furthermore, an increased permeability of the blood-brain barrier has been observed during periods of infection and inflammation. The authors therefore investigated whether autoimmune diseases combined with exposures to severe infections may increase the risk of schizophrenia",

keywords = "Adolescent, Adult, Autoimmune Diseases, Cohort Studies, Denmark, Female, Humans, Incidence, Infection, Male, Middle Aged, Registries, Risk, Risk Factors, Schizophrenia",

author = "Benros, {Michael E} and Nielsen, {Philip R} and Merete Nordentoft and Eaton, {William W} and Dalton, {Susanne Oksbjerg} and Mortensen, {Preben Bo}",

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doi = "10.1176/appi.ajp.2011.11030516",

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T2 - a 30-year population-based register study

AU - Benros, Michael E

AU - Nielsen, Philip R

AU - Nordentoft, Merete

AU - Eaton, William W

AU - Dalton, Susanne Oksbjerg

AU - Mortensen, Preben Bo

PY - 2011

Y1 - 2011

N2 - Autoimmune diseases have been associated with an increased risk of schizophrenia. It has been suggested that brain-reactive autoantibodies are part of the mechanisms behind this association. Furthermore, an increased permeability of the blood-brain barrier has been observed during periods of infection and inflammation. The authors therefore investigated whether autoimmune diseases combined with exposures to severe infections may increase the risk of schizophrenia

AB - Autoimmune diseases have been associated with an increased risk of schizophrenia. It has been suggested that brain-reactive autoantibodies are part of the mechanisms behind this association. Furthermore, an increased permeability of the blood-brain barrier has been observed during periods of infection and inflammation. The authors therefore investigated whether autoimmune diseases combined with exposures to severe infections may increase the risk of schizophrenia

KW - Adolescent

KW - Adult

KW - Autoimmune Diseases

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Humans

KW - Incidence

KW - Infection

KW - Male

KW - Middle Aged

KW - Registries

KW - Risk

KW - Risk Factors

KW - Schizophrenia

U2 - 10.1176/appi.ajp.2011.11030516

DO - 10.1176/appi.ajp.2011.11030516

M3 - Journal article

C2 - 22193673

SN - 0002-953X

VL - 168

SP - 1303

EP - 1310

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

IS - 12

ER -

Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study

Abstract

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