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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Autoimmune and Atopic Disorders and Risk of Classical Hodgkin Lymphoma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Peter Hollander
  • Klaus Rostgaard
  • Karin E Smedby
  • Ellen T Chang
  • Rose-Marie Amini
  • Peter de Nully Brown
  • Bengt Glimelius
  • Hans-Olov Adami
  • Mads Melbye
  • Ingrid Glimelius
  • Henrik Hjalgrim
Vis graf over relationer

Results from previous investigations have shown associations between the risk of Hodgkin lymphoma (HL) and a history of autoimmune and atopic diseases, but it remains unknown whether these associations apply to all types of HL or only to specific subtypes. We investigated immune diseases and the risk of classical HL in a population-based case-control study that included 585 patients and 3,187 controls recruited from October 1999 through August 2002. We collected information on immune diseases through telephone interviews and performed serological analyses of specific immunoglobulin E reactivity. Tumor Epstein-Barr virus (EBV) status was determined for 498 patients. Odds ratios with 95% confidence intervals were calculated using logistic regression analysis. Rheumatoid arthritis was associated with a higher risk of HL (odds ratio (OR) = 2.63; 95% confidence interval (CI): 1.47, 4.70), especially EBV-positive HL (OR = 3.18; 95% CI: 1.23, 8.17), and with mixed-cellularity HL (OR = 4.25; 95% CI: 1.66, 10.90). HL risk was higher when we used proxies of severe rheumatoid arthritis, such as ever having received daily rheumatoid arthritis medication (OR = 3.98; 95% CI: 2.08, 7.62), rheumatoid arthritis duration of 6-20 years (OR = 3.80; 95% CI: 1.72, 8.41), or ever having been hospitalized for rheumatoid arthritis (OR = 7.36; 95% CI: 2.95, 18.38). Atopic diseases were not associated with the risk of HL. EBV replication induced by chronic inflammation in patients with autoimmune diseases might explain the higher risk of EBV-positive HL.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Epidemiology
Vol/bind182
Udgave nummer7
Sider (fra-til)624-32
Antal sider9
ISSN0002-9262
DOI
StatusUdgivet - 1 okt. 2015

ID: 46177763