TY - JOUR
T1 - Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy
AU - Nørgaard, Pernille
AU - Wright, Dave
AU - Ball, Susan
AU - Newell, Paul
AU - Kirkegaard, Ida Sejersdahl
AU - Petersen, Olav Bjørn
AU - Uldbjerg, Niels
AU - Tørring, Niels
AU - Jørgensen, Finn Stener
AU - Friis-Hansen, Lennart
AU - Ekelund, Charlotte
AU - Tabor, Ann
AU - Sørensen, Steen
PY - 2013/9
Y1 - 2013/9
N2 - Theoretically, repeated sampling of free β-human chorionic gonadotropin (hCGβ) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester of pregnancy might improve performance of risk assessment of trisomy 21 (T21). To assess the performance of a screening test involving repeated measures of biochemical markers, correlations between markers must be estimated. The aims of this study were to calculate the autocorrelation and cross-correlation between hCGβ and PAPP-A in the first trimester of pregnancy and to investigate the possible impact of gestational age at the first sample and time between sampling on the correlation.
AB - Theoretically, repeated sampling of free β-human chorionic gonadotropin (hCGβ) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester of pregnancy might improve performance of risk assessment of trisomy 21 (T21). To assess the performance of a screening test involving repeated measures of biochemical markers, correlations between markers must be estimated. The aims of this study were to calculate the autocorrelation and cross-correlation between hCGβ and PAPP-A in the first trimester of pregnancy and to investigate the possible impact of gestational age at the first sample and time between sampling on the correlation.
U2 - 10.1515/cclm-2012-0805
DO - 10.1515/cclm-2012-0805
M3 - Journal article
C2 - 23612665
SN - 1434-6621
VL - 51
SP - 1781
EP - 1788
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 9
ER -