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Udgivet

Autoantibodies and immunoglobulins in alcoholic steatosis and cirrhosis

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  1. Increased plasma fibronectin concentrations in obesity: normalization during weight loss

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  2. Home readings of blood pressure in assessment of hypertensive subjects

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  3. The influence of insulin on the raised plasma fibronectin concentration in human obesity

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  4. Metabolic responses to hypoglycemia in juvenile diabetics

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Antinuclear antibodies were significantly more prevalent (p less than 0.01) in 143 patients with alcoholic cirrhosis than in 64 patients with alcoholic steatosis and in 94 controls. Smooth muscle antibodies were significantly more prevalent (p less than 0.05) in patients with alcoholic steatosis and cirrhosis than in controls. The prevalence of antimitochondrial antibodies and IgG liver membrane antibodies did not differ significantly between the three groups. Immunoglobulin G, A, and M concentrations were only occasionally increased in patients with steatosis. Patients with cirrhosis had significantly increased (p less than 0.005) concentrations of immunoglobulins G, A, and M when compared to patients with steatosis. These results indicate that the degree of liver damage has more effect than chronic alcoholism on the humoral immune system. Whether this influence is direct or indirect remains to be established.
OriginalsprogEngelsk
TidsskriftActa medica Scandinavica. Supplementum
Vol/bind214
Udgave nummer1
Sider (fra-til)61-6
Antal sider6
ISSN0365-463X
StatusUdgivet - 1983

ID: 38931359