@article{9109e5133de54ce2926c30f440ba8879,
title = "Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa",
abstract = "Effects of treatment with tobramycin initiated 1 or 24 h post-infection were investigated in a new version of a pulmonary infection model in mice. The model reflects the differentiated behaviour of Pseudomonas aeruginosa mucoid strains isolated from the lungs of one chronically infected cystic fibrosis (CF) patient at different time periods during chronic lung infection.",
keywords = "Animals, Anti-Bacterial Agents, Chemokine CXCL2, Colony Count, Microbial, Cystic Fibrosis, Disease Models, Animal, Female, Granulocyte Colony-Stimulating Factor, Humans, Lung, Mice, Mice, Inbred BALB C, Pneumonia, Bacterial, Pseudomonas Infections, Pseudomonas aeruginosa, Severity of Illness Index, Time Factors, Tobramycin",
author = "{van Gennip}, Maria and Claus Moser and Christensen, {Louise D} and Thomas Bjarnsholt and Henrik Calum and Jensen, {Peter {\O}} and Lars Christophersen and Hougen, {Hans Petter} and Oana Ciofu and S{\o}ren Molin and Michael Givskov and Niels H{\o}iby",
year = "2009",
month = dec,
day = "1",
doi = "10.1093/jac/dkp352",
language = "English",
volume = "64",
pages = "1241--50",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "6",
}