Attenuated purinergic receptor function in patients with type 2 diabetes

Pia Thaning; Laurids T Bune; Ylva Hellsten; Henriette Pilegaard; Bengt Saltin; Jaya B Rosenmeier

doi:10.2337/db09-1068

Attenuated purinergic receptor function in patients with type 2 diabetes

Pia Thaning, Laurids T Bune, Ylva Hellsten, Henriette Pilegaard, Bengt Saltin, Jaya B Rosenmeier

43 Citationer (Scopus)

Abstract

Extracellular nucleotides and nucleosides are involved in regulation of skeletal muscle blood flow. Diabetes induces cardiovascular dysregulation, but the extent to which the vasodilatatory capacity of nucleotides and nucleosides is affected in type 2 diabetes is unknown. The present study investigated 1) the vasodilatatory effect of ATP, uridine-triphosphate (UTP), and adenosine (ADO) and 2) the expression and distribution of P2Y(2) and P2X(1) receptors in skeletal muscles of diabetic subjects.

Originalsprog	Engelsk
Tidsskrift	Diabetes
Vol/bind	59
Udgave nummer	1
Sider (fra-til)	182-9
Antal sider	8
DOI	https://doi.org/10.2337/db09-1068
Status	Udgivet - 1 jan. 2010

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10.2337/db09-1068

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abstract = "Extracellular nucleotides and nucleosides are involved in regulation of skeletal muscle blood flow. Diabetes induces cardiovascular dysregulation, but the extent to which the vasodilatatory capacity of nucleotides and nucleosides is affected in type 2 diabetes is unknown. The present study investigated 1) the vasodilatatory effect of ATP, uridine-triphosphate (UTP), and adenosine (ADO) and 2) the expression and distribution of P2Y(2) and P2X(1) receptors in skeletal muscles of diabetic subjects.",

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AU - Thaning, Pia

AU - Bune, Laurids T

AU - Hellsten, Ylva

AU - Pilegaard, Henriette

AU - Saltin, Bengt

AU - Rosenmeier, Jaya B

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Extracellular nucleotides and nucleosides are involved in regulation of skeletal muscle blood flow. Diabetes induces cardiovascular dysregulation, but the extent to which the vasodilatatory capacity of nucleotides and nucleosides is affected in type 2 diabetes is unknown. The present study investigated 1) the vasodilatatory effect of ATP, uridine-triphosphate (UTP), and adenosine (ADO) and 2) the expression and distribution of P2Y(2) and P2X(1) receptors in skeletal muscles of diabetic subjects.

AB - Extracellular nucleotides and nucleosides are involved in regulation of skeletal muscle blood flow. Diabetes induces cardiovascular dysregulation, but the extent to which the vasodilatatory capacity of nucleotides and nucleosides is affected in type 2 diabetes is unknown. The present study investigated 1) the vasodilatatory effect of ATP, uridine-triphosphate (UTP), and adenosine (ADO) and 2) the expression and distribution of P2Y(2) and P2X(1) receptors in skeletal muscles of diabetic subjects.

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DO - 10.2337/db09-1068

M3 - Journal article

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VL - 59

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Attenuated purinergic receptor function in patients with type 2 diabetes

Abstract

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