Attenuated apoptosis response to Fas-ligand in active ulcerative colitis

Jakob B Seidelin; Ole H Nielsen

doi:10.1002/ibd.20629

Attenuated apoptosis response to Fas-ligand in active ulcerative colitis

21 Citationer (Scopus)

Abstract

From mainly carcinoma cell line studies, apoptosis has been thought to play a major role in the pathogenesis of ulcerative colitis (UC). Apoptosis has been suggested to be due to a Fas ligand / Fas receptor interaction, but has never been studied in cells from patients with active UC. The aim was to investigate both the spontaneous and the cell death receptor ligand-induced apoptosis in UC.

Originalsprog	Engelsk
Tidsskrift	Inflammatory Bowel Diseases
Vol/bind	14
Udgave nummer	12
Sider (fra-til)	1623-9
Antal sider	7
ISSN	1078-0998
DOI	https://doi.org/10.1002/ibd.20629
Status	Udgivet - 2008

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10.1002/ibd.20629

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title = "Attenuated apoptosis response to Fas-ligand in active ulcerative colitis",

abstract = "From mainly carcinoma cell line studies, apoptosis has been thought to play a major role in the pathogenesis of ulcerative colitis (UC). Apoptosis has been suggested to be due to a Fas ligand / Fas receptor interaction, but has never been studied in cells from patients with active UC. The aim was to investigate both the spontaneous and the cell death receptor ligand-induced apoptosis in UC.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Antigens, CD95, Antiviral Agents, Apoptosis, Case-Control Studies, Cells, Cultured, Colitis, Ulcerative, Colon, Fas Ligand Protein, Female, Flow Cytometry, Fluorescent Antibody Technique, HT29 Cells, Humans, Interferon-gamma, Male, Middle Aged, Young Adult",

author = "Seidelin, {Jakob B} and Nielsen, {Ole H}",

year = "2008",

doi = "10.1002/ibd.20629",

language = "English",

volume = "14",

pages = "1623--9",

journal = "Inflammatory Bowel Diseases",

issn = "1078-0998",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Attenuated apoptosis response to Fas-ligand in active ulcerative colitis

AU - Seidelin, Jakob B

AU - Nielsen, Ole H

PY - 2008

Y1 - 2008

N2 - From mainly carcinoma cell line studies, apoptosis has been thought to play a major role in the pathogenesis of ulcerative colitis (UC). Apoptosis has been suggested to be due to a Fas ligand / Fas receptor interaction, but has never been studied in cells from patients with active UC. The aim was to investigate both the spontaneous and the cell death receptor ligand-induced apoptosis in UC.

AB - From mainly carcinoma cell line studies, apoptosis has been thought to play a major role in the pathogenesis of ulcerative colitis (UC). Apoptosis has been suggested to be due to a Fas ligand / Fas receptor interaction, but has never been studied in cells from patients with active UC. The aim was to investigate both the spontaneous and the cell death receptor ligand-induced apoptosis in UC.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD95

KW - Antiviral Agents

KW - Apoptosis

KW - Case-Control Studies

KW - Cells, Cultured

KW - Colitis, Ulcerative

KW - Colon

KW - Fas Ligand Protein

KW - Female

KW - Flow Cytometry

KW - Fluorescent Antibody Technique

KW - HT29 Cells

KW - Humans

KW - Interferon-gamma

KW - Male

KW - Middle Aged

KW - Young Adult

U2 - 10.1002/ibd.20629

DO - 10.1002/ibd.20629

M3 - Journal article

C2 - 18680199

SN - 1078-0998

VL - 14

SP - 1623

EP - 1629

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

IS - 12

ER -

Attenuated apoptosis response to Fas-ligand in active ulcerative colitis

Abstract

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