Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Attempts to Target Staphylococcus aureus Induced Osteomyelitis Bone Lesions in a Juvenile Pig Model by Using Radiotracers

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Cholecystokinin and panic disorder: reflections on the history and some unsolved questions

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Evaluation of [64Cu]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In]In-DOTA-PEG11-BisPy-Tz

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Granulomatøs dermatitis på PET

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. [99mTc]-labelled interleukin-8 as a diagnostic tool compared to [18F]FDG and CT in an experimental porcine osteomyelitis model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Lungeembolus hos en patient med COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

  • Pia Afzelius
  • Aage Kristian Olsen Alstrup
  • Ole Lerberg Nielsen
  • Karin Michaelsen Nielsen
  • Svend Borup Jensen
Vis graf over relationer

Background [18F]FDG Positron Emission Tomography cannot differentiate between sterile inflammation and infection. Therefore, we, aimed to develop more specific radiotracers fitted for differentiation between sterile and septic infection to improve the diagnostic accuracy. Consequently, the clinicians can refine the treatment of, for example, prosthesis-related infection.

METHODS: We examined different target points; Staphylococcus aureus biofilm (68Ga-labeled DOTA-K-A9 and DOTA-GSGK-A11), bone remodeling ([18F]NaF), bacterial cell membranes ([68Ga]Ga-Ubiquicidin), and leukocyte trafficking ([68Ga]Ga-DOTA-Siglec-9). We compared them to the well-known glucose metabolism marker [18F]FDG, in a well-established juvenile S. aureus induced osteomyelitis (OM) pig model.

RESULTS: [18F]FDG accumulated in the OM lesions seven days after bacterial inoculation, but disappointingly we were not able to identify any tracer accumulation in OM with any of the supposedly more specific tracers.

CONCLUSION: These negative results are, however, relevant to report as they may save other research groups from conducting the same animal experiments and provide a platform for developing and evaluating other new potential tracers or protocol instead.

Udgave nummer18
StatusUdgivet - 21 sep. 2020

ID: 60905301