TY - JOUR
T1 - Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors
AU - Mikkelsen, Susan
AU - Boldsen, Jens Kjærgaard
AU - Møller, Bjarne Kuno
AU - Dinh, Khoa Manh
AU - Rostgaard, Klaus
AU - Petersen, Mikkel Steen
AU - Kaspersen, Kathrine Agergård
AU - Pedersen, Ole Birger
AU - Thørner, Lise Wegner
AU - Handgaard, Linda Jenny
AU - Ostrowski, Sisse Rye
AU - Sigsgaard, Torben
AU - Erikstrup, Christian
N1 - Copyright © 2021. Published by Elsevier B.V.
PY - 2021/9
Y1 - 2021/9
N2 - BACKGROUND AND AIMS: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma are characterized by activation of the immune system. The aim of this study was to explore the long-term association between AR, AC, asthma, and specific immunoglobulin E (IgE) and blood platelet and leukocyte differential counts.MATERIAL AND METHODS: In the Danish Blood Donor Study, 14,440 participants from Central Denmark Region had platelet and leukocyte differential counts available and completed a questionnaire regarding AR, AC, and asthma. Of these participants, 8485 were tested for IgE to inhalation allergens.RESULTS: The prevalence of AR, AC, asthma, and IgE sensitization was 19%, 15%, 9%, and 29%, respectively. AR, AC, asthma, wheeze, and IgE sensitization was associated with increased blood eosinophil concentration even in IgE sensitized participants who did not report any allergy or asthma. The strongest associations were observed for participants with current disease. We found no differences in eosinophil concentration between months without symptoms and months with symptoms of AR and asthma.CONCLUSION: AR, AC, asthma, wheezing, and IgE sensitization to inhalation allergens are associated with increased eosinophil concentration. This may reflect a persistent inflammation even in periods without symptomatic disease.
AB - BACKGROUND AND AIMS: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma are characterized by activation of the immune system. The aim of this study was to explore the long-term association between AR, AC, asthma, and specific immunoglobulin E (IgE) and blood platelet and leukocyte differential counts.MATERIAL AND METHODS: In the Danish Blood Donor Study, 14,440 participants from Central Denmark Region had platelet and leukocyte differential counts available and completed a questionnaire regarding AR, AC, and asthma. Of these participants, 8485 were tested for IgE to inhalation allergens.RESULTS: The prevalence of AR, AC, asthma, and IgE sensitization was 19%, 15%, 9%, and 29%, respectively. AR, AC, asthma, wheeze, and IgE sensitization was associated with increased blood eosinophil concentration even in IgE sensitized participants who did not report any allergy or asthma. The strongest associations were observed for participants with current disease. We found no differences in eosinophil concentration between months without symptoms and months with symptoms of AR and asthma.CONCLUSION: AR, AC, asthma, wheezing, and IgE sensitization to inhalation allergens are associated with increased eosinophil concentration. This may reflect a persistent inflammation even in periods without symptomatic disease.
KW - Allergens
KW - Blood Donors
KW - Eosinophils
KW - Humans
KW - Hypersensitivity, Immediate/epidemiology
KW - Immunoglobulin E
KW - Rhinitis, Allergic
UR - http://www.scopus.com/inward/record.url?scp=85108719939&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2021.06.015
DO - 10.1016/j.cca.2021.06.015
M3 - Journal article
C2 - 34118238
VL - 520
SP - 139
EP - 146
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
ER -