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Region Hovedstaden - en del af Københavns Universitetshospital
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Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  • Mark E Lobatto
  • Claudia Calcagno
  • Antoine Millon
  • Max L Senders
  • Francois Fay
  • Philip M Robson
  • Sarayu Ramachandran
  • Tina Binderup
  • Maarten P M Paridaans
  • Steven Sensarn
  • Stephan Rogalla
  • Ronald E Gordon
  • Luis Cardoso
  • Gert Storm
  • Josbert M Metselaar
  • Christopher H Contag
  • Erik S G Stroes
  • Zahi A Fayad
  • Willem J M Mulder
Vis graf over relationer

Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis.

OriginalsprogEngelsk
TidsskriftACS Nano
Vol/bind9
Udgave nummer2
Sider (fra-til)1837-47
Antal sider11
ISSN1936-0851
DOI
StatusUdgivet - 24 feb. 2015

ID: 49876687