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Atherosclerosis and renal disease involvement in patients with systemic lupus erythematosus: a cross-sectional cohort study

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@article{4c849c43b63c4992a492cdbd34f75b5b,
title = "Atherosclerosis and renal disease involvement in patients with systemic lupus erythematosus: a cross-sectional cohort study",
abstract = "Objective: To investigate the association between LN, renal function and atherosclerosis measured by coronary artery calcium (CAC) and carotid plaque in a cross-sectional study of patients with SLE.Methods: Presence of CAC and carotid plaque was measured in 147 SLE patients with and without LN. The patients were divided into four groups according to LN and renal function [by first quartile of estimated glomerular filtration rate (eGFR): 70 ml/min/1.73 m2]. Impaired renal function was defined by an eGFR <70 ml/min/1.73 m2. We used multivariate logistic regression models to explore the association between LN, renal function, CAC and carotid plaque.Results: Of the 147 SLE patients, 74 had LN. Median age of the study cohort was 46 years, 89{\%} were women and median eGFR was 89 ml/min/1.73 m2. CAC score >0 was present in 57 (39{\%}) and carotid plaque in 29 (20{\%}) of the SLE patients. The presence of CAC and/or carotid plaque was highest in SLE patients with impaired renal function. Regression analyses showed that compared with SLE patients without LN and eGFR ⩾70 ml/min/1.73 m2 (reference group), only the combination of LN and impaired renal function was associated with the presence of CAC (odds ratio: 6.82, 95{\%} CI: 1.59, 29; P = 0.01) and carotid plaque (odds ratio: 5.60, 95{\%} CI: 1.19, 26; P = 0.03).Conclusion: Our findings indicate that LN in combination with impaired renal function defined by an eGFR <70 ml/min/1.73 m2 is strongly associated with the presence of atherosclerosis in SLE.",
author = "Marie-Louise Hermansen and Benjamin Sandholt and Andreas Fuchs and Henrik Sillesen and Lars K{\o}ber and Kofoed, {Klaus Fuglsang} and Mikkel Faurschou and S{\o}ren Jacobsen",
year = "2018",
doi = "10.1093/rheumatology/key201",
language = "English",
volume = "57",
pages = "1964--1971",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Atherosclerosis and renal disease involvement in patients with systemic lupus erythematosus

T2 - a cross-sectional cohort study

AU - Hermansen, Marie-Louise

AU - Sandholt, Benjamin

AU - Fuchs, Andreas

AU - Sillesen, Henrik

AU - Køber, Lars

AU - Kofoed, Klaus Fuglsang

AU - Faurschou, Mikkel

AU - Jacobsen, Søren

PY - 2018

Y1 - 2018

N2 - Objective: To investigate the association between LN, renal function and atherosclerosis measured by coronary artery calcium (CAC) and carotid plaque in a cross-sectional study of patients with SLE.Methods: Presence of CAC and carotid plaque was measured in 147 SLE patients with and without LN. The patients were divided into four groups according to LN and renal function [by first quartile of estimated glomerular filtration rate (eGFR): 70 ml/min/1.73 m2]. Impaired renal function was defined by an eGFR <70 ml/min/1.73 m2. We used multivariate logistic regression models to explore the association between LN, renal function, CAC and carotid plaque.Results: Of the 147 SLE patients, 74 had LN. Median age of the study cohort was 46 years, 89% were women and median eGFR was 89 ml/min/1.73 m2. CAC score >0 was present in 57 (39%) and carotid plaque in 29 (20%) of the SLE patients. The presence of CAC and/or carotid plaque was highest in SLE patients with impaired renal function. Regression analyses showed that compared with SLE patients without LN and eGFR ⩾70 ml/min/1.73 m2 (reference group), only the combination of LN and impaired renal function was associated with the presence of CAC (odds ratio: 6.82, 95% CI: 1.59, 29; P = 0.01) and carotid plaque (odds ratio: 5.60, 95% CI: 1.19, 26; P = 0.03).Conclusion: Our findings indicate that LN in combination with impaired renal function defined by an eGFR <70 ml/min/1.73 m2 is strongly associated with the presence of atherosclerosis in SLE.

AB - Objective: To investigate the association between LN, renal function and atherosclerosis measured by coronary artery calcium (CAC) and carotid plaque in a cross-sectional study of patients with SLE.Methods: Presence of CAC and carotid plaque was measured in 147 SLE patients with and without LN. The patients were divided into four groups according to LN and renal function [by first quartile of estimated glomerular filtration rate (eGFR): 70 ml/min/1.73 m2]. Impaired renal function was defined by an eGFR <70 ml/min/1.73 m2. We used multivariate logistic regression models to explore the association between LN, renal function, CAC and carotid plaque.Results: Of the 147 SLE patients, 74 had LN. Median age of the study cohort was 46 years, 89% were women and median eGFR was 89 ml/min/1.73 m2. CAC score >0 was present in 57 (39%) and carotid plaque in 29 (20%) of the SLE patients. The presence of CAC and/or carotid plaque was highest in SLE patients with impaired renal function. Regression analyses showed that compared with SLE patients without LN and eGFR ⩾70 ml/min/1.73 m2 (reference group), only the combination of LN and impaired renal function was associated with the presence of CAC (odds ratio: 6.82, 95% CI: 1.59, 29; P = 0.01) and carotid plaque (odds ratio: 5.60, 95% CI: 1.19, 26; P = 0.03).Conclusion: Our findings indicate that LN in combination with impaired renal function defined by an eGFR <70 ml/min/1.73 m2 is strongly associated with the presence of atherosclerosis in SLE.

U2 - 10.1093/rheumatology/key201

DO - 10.1093/rheumatology/key201

M3 - Journal article

VL - 57

SP - 1964

EP - 1971

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 11

ER -

ID: 55217334