Asthma-like Symptoms in Young Children Increase the Risk of COPD

Hans Bisgaard, Sarah Nørgaard, Astrid Sevelsted, Bo Chawes, Jakob Stokholm, Erik Lykke Mortensen, Charlotte Suppli Ulrik, Klaus Bønnelykke

20 Citationer (Scopus)


Background: Chronic obstructive pulmonary disease (COPD) may originate in early life and share disease mechanisms with asthma-like symptoms in early childhood. This possibility remains unexplored on account of the lack of long-term prospective studies from infancy to the onset of COPD. Objective: We aimed to investigate the relationship between asthma-like symptoms in young children and development of COPD. Methods: In a population-based cohort of women who gave birth at the central hospital in Copenhagen during period from 1959 to 1961, we investigated data from 3290 mother-child pairs who attended examinations during pregnancy and when the children were aged 1, 3, and 6 years. COPD was assessed from the Danish national registries on hospitalizations and prescription medication since 1994. A subgroup of 930 individuals underwent spirometry testing at age 50 years. Results: Of the 3290 children, 1 in 4 had a history of asthma-like symptoms in early childhood. The adjusted hazard ratio for hospitalization for COPD was 1.88 (95% CI = 1.32-2.68), and the odds ratio for prescription of long-acting muscarinic antagonists was 2.27 (95% CI = 1.38-3.70). Asthma-like symptoms in early childhood were also associated with a reduced FEV 1 percent predicted and an FEV 1-to–forced vital capacity ratio at age 50 years (–3.36% [95% CI = –5.47 to –1.24] and –1.28 [95% CI = –2.17 to –0.38], respectively) and with COPD defined according to Global Initiative for Chronic Obstructive Lung Disease stage higher than 1 (odds ratio = 1.96 [95% CI = 1.13-3.34]). Conclusion: This 60-year prospective follow-up of a mother-child cohort demonstrated a doubled risk for COPD from childhood asthma-like symptoms.

TidsskriftThe Journal of allergy and clinical immunology
Udgave nummer2
Sider (fra-til)569-576
Antal sider7
StatusUdgivet - 1 feb. 2021


Dyk ned i forskningsemnerne om 'Asthma-like Symptoms in Young Children Increase the Risk of COPD'. Sammen danner de et unikt fingeraftryk.