@article{8910a25e686f4f9c895b3829f332339f,
title = "Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex",
abstract = "Associative high-frequency electrical stimulation (HFS) of the supraorbital nerve in five healthy individuals induced long-term potentiation (LTP)-like or depression (LTD)-like changes in the human blink reflex circuit according to the rules of spike timing-dependent plasticity (Mao and Evinger, 2001). HFS given at the onset of the R2 component of the blink reflex (HFS(LTP)) produced a lasting facilitation of the R2, whereas HFS given shortly before R2 (HFS(LTD)) caused a lasting suppression of the R2. In patients with benign essential blepharospasm (BEB), a focal dystonia affecting the orbicularis oculi muscles, HFS(LTP) induced excessive LTP-like associative plasticity relative to healthy controls, which was normalized after botulinum toxin (BTX) injections (Quartarone et al, 2006).",
author = "Zeuner, {Kirsten E} and Arne Knutzen and Asmaa Al-Ali and Mark Hallett and G{\"u}nther Deuschl and Bergmann, {Til O} and Siebner, {Hartwig R}",
year = "2010",
doi = "10.1371/journal.pone.0013602",
language = "English",
volume = "5",
pages = "e13602",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",
}