TY - JOUR
T1 - Associations of weight and body composition at birth with body composition and cardiometabolic markers in children aged 10 years
T2 - the Ethiopian infant anthropometry and body composition birth cohort study
AU - Megersa, Bikila S
AU - Beakal Zinab, null
AU - Ali, Rahma
AU - Kedir, Elias
AU - Girma, Tsinuel
AU - Berhane, Melkamu
AU - Admasu, Bitiya
AU - Friis, Henrik
AU - Abera, Mubarek
AU - Olsen, Mette F
AU - Filteau, Suzanne
AU - Nitsch, Dorothea
AU - Yilma, Daniel
AU - Wells, Jonathan Ck
AU - Andersen, Gregers S
AU - Wibaek, Rasmus
N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2023/8
Y1 - 2023/8
N2 - BACKGROUND: Although birth weight (BW) has been associated with later cardiovascular disease and type 2 diabetes, the role of birth fat mass (BFM) and birth fat-free mass (BFFM) on cardiometabolic health is unclear.OBJECTIVES: To examine associations of BW, BFM, and BFFM with later anthropometry, body composition, abdominal fat, and cardiometabolic markers.METHODS: Birth cohort data on standardized exposure variables (BW, BFM, and BFFM) and follow-up information at age 10 y on anthropometry, body composition, abdominal fat, and cardiometabolic markers were included. A linear regression analysis was used to assess associations of exposures with outcome variables, adjusting for maternal and child characteristics at birth and current body size in separate models.RESULTS: Among 353 children, mean (SD) age was 9.8 (1.0) y, and 51.5% were boys. In the fully adjusted model, 1-SD higher BW and BFFM were associated with 0.81 cm (95% CI: 0.21, 1.41 cm) and 1.25 cm (95% CI: 0.64, 1.85 cm) greater height at 10 y, respectively. The 1-SD higher BW and BFM were associated with 0.32 kg/m
2 (95% CI: 0.14, 0.51 kg/m
2) and 0.42 kg/m
2 (95% CI: 0.25, 0.59 kg/m
2) greater fat mass index at 10 y, respectively. In addition, 1-SD higher BW and BFFM were associated with 0.22 kg/m
2 (95% CI: 0.09, 0.34 kg/m
2) greater FFM index, whereas a 1-SD greater BFM was associated with a 0.05 cm greater subcutaneous adipose tissue (95% CI: 0.01, 0.11 cm). Furthermore, 1-SD higher BW and BFFM were associated with 10.3% (95% CI: 1.4%, 20.0%) and 8.3% (95% CI: -0.5%, 17.9%) greater insulin, respectively. Similarly, 1-SD higher BW and BFFM were associated with 10.0% (95% CI: 0.9%, 20.0%) and 8.5% (95% CI: -0.6%, 18.5%) greater homeostasis model assessment of insulin resistance, respectively.
CONCLUSIONS: BW and BFFM rather than BFM are predictors of height and FFM index at 10 y. Children with higher BW and BFFM showed higher insulin concentrations and homeostasis model assessment of insulin resistance at 10 y of age. This trial was registered at ISRCTN as ISRCTN46718296.
AB - BACKGROUND: Although birth weight (BW) has been associated with later cardiovascular disease and type 2 diabetes, the role of birth fat mass (BFM) and birth fat-free mass (BFFM) on cardiometabolic health is unclear.OBJECTIVES: To examine associations of BW, BFM, and BFFM with later anthropometry, body composition, abdominal fat, and cardiometabolic markers.METHODS: Birth cohort data on standardized exposure variables (BW, BFM, and BFFM) and follow-up information at age 10 y on anthropometry, body composition, abdominal fat, and cardiometabolic markers were included. A linear regression analysis was used to assess associations of exposures with outcome variables, adjusting for maternal and child characteristics at birth and current body size in separate models.RESULTS: Among 353 children, mean (SD) age was 9.8 (1.0) y, and 51.5% were boys. In the fully adjusted model, 1-SD higher BW and BFFM were associated with 0.81 cm (95% CI: 0.21, 1.41 cm) and 1.25 cm (95% CI: 0.64, 1.85 cm) greater height at 10 y, respectively. The 1-SD higher BW and BFM were associated with 0.32 kg/m
2 (95% CI: 0.14, 0.51 kg/m
2) and 0.42 kg/m
2 (95% CI: 0.25, 0.59 kg/m
2) greater fat mass index at 10 y, respectively. In addition, 1-SD higher BW and BFFM were associated with 0.22 kg/m
2 (95% CI: 0.09, 0.34 kg/m
2) greater FFM index, whereas a 1-SD greater BFM was associated with a 0.05 cm greater subcutaneous adipose tissue (95% CI: 0.01, 0.11 cm). Furthermore, 1-SD higher BW and BFFM were associated with 10.3% (95% CI: 1.4%, 20.0%) and 8.3% (95% CI: -0.5%, 17.9%) greater insulin, respectively. Similarly, 1-SD higher BW and BFFM were associated with 10.0% (95% CI: 0.9%, 20.0%) and 8.5% (95% CI: -0.6%, 18.5%) greater homeostasis model assessment of insulin resistance, respectively.
CONCLUSIONS: BW and BFFM rather than BFM are predictors of height and FFM index at 10 y. Children with higher BW and BFFM showed higher insulin concentrations and homeostasis model assessment of insulin resistance at 10 y of age. This trial was registered at ISRCTN as ISRCTN46718296.
KW - abdominal fat
KW - air displacement plethysmograph
KW - birth fat mass
KW - birth fat-free mass
KW - birth weight
KW - cardiometabolic markers
KW - children
KW - cohort study
KW - Ethiopia
UR - http://www.scopus.com/inward/record.url?scp=85164413301&partnerID=8YFLogxK
U2 - 10.1016/j.ajcnut.2023.06.010
DO - 10.1016/j.ajcnut.2023.06.010
M3 - Journal article
C2 - 37328067
SN - 0002-9165
VL - 118
SP - 412
EP - 421
JO - The American journal of clinical nutrition
JF - The American journal of clinical nutrition
IS - 2
ER -