Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Associations of Plasma Nitrite, L-Arginine and Asymmetric Dimethylarginine with Morbidity and Mortality in Patients with Necrotizing Soft Tissue Infections

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Absences of Endothelial Microvesicle Changes in the Presence of the Endotheliopathy of Trauma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Acute Lung Injury in Critically Ill Patients: Actin-Scavenger Gelsolin Signals Prolonged Respiratory Failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Lactate is a Prognostic Factor in Patients Admitted with Suspected ST-Elevation Myocardial Infarction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Transfusion Strategies are Associated with Epigenetic Changes Following Blunt Trauma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Only minor stem cell mobilization in head and neck irradiated patients treated with hyperbaric oxygen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Outcomes of Prophylactic Pantoprazole in Adult Intensive Care Unit Patients Receiving Dialysis: Results of a Randomized Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Time to onset of gastrointestinal bleeding in the SUP-ICU trial: a preplanned substudy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The nitric oxide system could play an important role in the pathophysiology related to necrotizing soft tissue infection (NSTI). Accordingly, we investigated the association between plasma nitrite level at admission and the presence of septic shock in patients with NSTI. We also evaluated the association between nitrite, asymmetric dimethylarginine (ADMA), L-arginine, L-arginine/ADMA-ratio and outcome.

METHODS: We analyzed plasma from 141 NSTI patients taken upon hospital admission. The severity of NSTI was assessed by the presence of septic shock, SAPS II, SOFA score, use of renal replacement therapy (RRT), amputation and 28-day mortality.

RESULTS: No difference in nitrite levels was found between patients with and without septic shock (median 0.82 μmol/L (IQR 0.41-1.21) vs. 0.87 μmol/L (0.62-1.24), p = 0.25). ADMA level was higher in patients in need of RRT (0.64 μmol/L (IQR 0.47-0.90) vs. (0.52 μmol/L (0.34-0.70), p = 0.028), and ADMA levels correlated positively with SAPS II (rho = 0.32, p = 0.0002) and SOFA scores (rho = 0.22, p = 0.01). In a logistic regression analysis, an L-arginine/ADMA-ratio below 101.59 was independently associated with 28-day mortality, OR 6.03 (95% CI, 1.41-25.84), p = 0.016. None of the other analyses indicated differences in the NO-system based on differences in disease severity.

CONCLUSIONS: In patients with NSTI, we found no difference in baseline nitrite levels according to septic shock. High baseline ADMA level was associated with the use of RRT and patients with a low baseline L-arginine/ADMA-ratio were at higher risk of dying within 28 days after hospital admission.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0.

OriginalsprogEngelsk
TidsskriftShock
Vol/bind49
Udgave nummer6
Sider (fra-til)667-74
ISSN1073-2322
DOI
StatusUdgivet - 2018

ID: 51804500