Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Associations of objective physical activity with insulin sensitivity and circulating adipokine profile: the Framingham Heart Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Shorter preschool, leukocyte telomere length is associated with obesity at age 9 in Latino children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Liver fat content by magnetic resonance spectroscopy in obese children and youths included in multidisciplinary treatment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A 60-year-old obese woman with osteoarthritis of the knee: a case-report.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Osteoarthritis – a role for weight management in rheumatology practice: an update

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Polygenic predisposition to breast cancer and the risk of coronary artery disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Prevalence of heart failure and other risk factors among first-degree relatives of women with peripartum cardiomyopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Outcomes associated with dual antiplatelet therapy after myocardial infarction in patients with aortic stenosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • N L Spartano
  • M D Stevenson
  • V Xanthakis
  • M G Larson
  • C Andersson
  • J M Murabito
  • R S Vasan
Vis graf over relationer

The purpose of this study was to explore the relation of physical activity (PA) and sedentary time (SED) to insulin sensitivity and adipokines. We assessed PA and SED using Actical accelerometers and insulin resistance (HOMA-IR) in 2109 participants (free of type 1 and 2 diabetes mellitus) from Framingham Generation 3 and Omni 2 cohorts (mean age 46 years, 54% women). Systemic inflammation (C-reactive protein [CRP]) and circulating adipokines were measured 6 years earlier. Steps per day, moderate-to-vigorous PA (MVPA) and SED per wear time (%SED) were predictor variables in multivariable regression analyses, with HOMA-IR, CRP and circulating adipokines as outcome measures. We reported that higher MVPA and more steps per day were associated with lower HOMA-IR, adjusting for %SED (β = -0.036, P = 0.002; β = -0.041, P = 0.005). Steps were inversely associated with CRP, but were directly associated with insulin-like growth factor (IGF)-1 levels (β = -0.111, P = 0.002; β = 3.293, P = 0.007). %SED was positively associated with HOMA-IR (β = 0.033, P < 0.0001), but non-significant after adjusting for MVPA (P = 0.13). %SED was associated with higher ratio of leptin/leptin receptor (sOB-R) and higher adipocyte fatty acid-binding protein (FABP)4 (β = 0.096, P < 0.0001; β = 0.593, P = 0.002). Our findings suggest differential influences of PA vs. SED on metabolic pathways, with PA modulating insulin resistance and inflammation, whereas SED influences FABPs.

OriginalsprogEngelsk
TidsskriftClinical Obesity
Vol/bind7
Udgave nummer2
Sider (fra-til)59-69
Antal sider11
DOI
StatusUdgivet - apr. 2017

ID: 52410872