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Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Adverse life events in the general population - a validation of the cumulative lifetime adversity measure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Psychosocial predictors of treatment outcome for trauma-affected refugees

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary psychotic symptoms (PTSD-SP), and 31 healthy controls (RHC) were interviewed and scanned with functional magnetic resonance imaging (fMRI) during a monetary incentive delay task. Using region of interest analysis of the prefrontal cortex and ventral striatum, we investigated reward-related activity. Results: Compared to RHC, participants with PTSD had decreased neural activity during monetary reward. Also, participants with PTSD-SP exhibited decreased activity in the associative striatum relative to participants with PTSD-NSP during processing of motivational reward anticipation which correlated with severity of psychotic symptoms. However, the difference between the two PTSD groups disappeared when PTSD severity and trauma exposure were accounted for. Conclusions: Anhedonia and secondary psychotic symptoms in PTSD are characterized by dysfunctional reward consumption and anticipation processing, respectively. The latter may reflect a mechanism by which abnormal reward signals in the basal ganglia facilitates psychotic symptoms across psychiatric conditions.

OriginalsprogEngelsk
Artikelnummer1730091
TidsskriftEuropean Journal of Psychotraumatology
Vol/bind11
Udgave nummer1
ISSN2000-8066
DOI
StatusUdgivet - 4 mar. 2020

Bibliografisk note

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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