Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men

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Abstract

Filaggrin is an epidermal protein that is crucial for skin barrier function. Up to 10% of Europeans and 5% of Asians carry at least one null allele in the filaggrin gene (FLG). Reduced expression of filaggrin in null allele carriers is associated with facilitated transfer of allergens across the epidermis. We hypothesized that these individuals may have increased transdermal uptake of endocrine disruptors, including phthalates.
OriginalsprogEngelsk
TidsskriftEnvironmental Health Perspectives
Vol/bind122
Udgave nummer4
Sider (fra-til)345-350
Antal sider5
ISSN0091-6765
DOI
StatusUdgivet - apr. 2014

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