Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Associations Between Cognitive Function and Levels of Glutamatergic Metabolites and Gamma-Aminobutyric Acid in Antipsychotic-Naïve Patients With Schizophrenia or Psychosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Dysregulated Lipid Metabolism Precedes Onset of Psychosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Meta-analysis of the Glial Marker TSPO in Psychosis Revisited: Reconciling Inconclusive Findings of Patient-Control Differences

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Volume of hippocampal subregions and clinical improvement following electroconvulsive therapy in patients with depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Intradural artery dilation during experimentally induced migraine attacks

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Abnormal glutamate and GABA (gamma-aminobutyric acid) levels have been found in the early phase of schizophrenia and may underlie cognitive deficits. However, the association between cognitive function and levels of glutamatergic metabolites and GABA has not been investigated in a large group of antipsychotic-naïve patients.

METHODS: In total, 56 antipsychotic-naïve patients with schizophrenia or psychotic disorder and 51 healthy control subjects underwent magnetic resonance spectroscopy to measure glutamate, glutamate+glutamine (Glx), and GABA levels in dorsal anterior cingulate cortex (ACC) and glutamate and Glx levels in left thalamus. The cognitive domains of attention, working memory, and IQ were assessed.

RESULTS: The whole group of antipsychotic-naïve patients had lower levels of GABA in dorsal ACC (p = .03), and the subgroup of patients with a schizophrenia diagnosis had higher glutamate levels in thalamus (p = .01), but Glx levels in dorsal ACC and thalamus did not differ between groups. Glx levels in dorsal ACC were positively associated with working memory (logarithmically transformed: b = -.016 [higher score indicates worse performance], p = .005) and attention (b = .056, p = .035) in both patients and healthy control subjects, although the association with attention did not survive adjustment for multiple comparisons.

CONCLUSIONS: The findings suggest a positive association between glutamatergic metabolites and cognitive function that do not differ between patients and healthy control subjects. Moreover, our data indicate that decreased GABAergic levels in dorsal ACC are involved in schizophrenia and psychotic disorder, whereas increased glutamate levels in thalamus seem to be implicated in schizophrenia pathophysiology. The findings imply that first-episode patients with cognitive deficits may gain from glutamate-modulating compounds.

OriginalsprogEngelsk
TidsskriftBiological Psychiatry
Vol/bind89
Udgave nummer3
Sider (fra-til)278-287
Antal sider10
ISSN0006-3223
DOI
StatusUdgivet - 1 feb. 2021

Bibliografisk note

Copyright © 2020 Society of Biological Psychiatry. All rights reserved.

ID: 61504503