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Associations between body mass index trajectories in childhood and cardiovascular risk factors in adulthood

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@article{66b2ba5419504aefa5de6bfee0b5c832,
title = "Associations between body mass index trajectories in childhood and cardiovascular risk factors in adulthood",
abstract = "BACKGROUND AND AIMS: Children with a growth trajectory of overweight have higher levels of cardiovascular disease (CVD) risk factors than children with a normal-weight trajectory. However, less is known about how trajectories of body mass index (BMI) across the rest of the BMI spectrum relate to CVD risk factors and whether adult BMI affects these associations. Our aim was to examine associations between childhood BMI trajectories and adult CVD risk factors.METHODS: We included 2466 individuals with childhood weights and heights (ages 6-14) from the Copenhagen School Health Records Register and adult CVD risk factors (ages 20-81) from the Copenhagen City Heart Study. Associations between childhood BMI trajectories identified by latent class modelling and CVD risk factors were examined using generalized linear regression analyses with and without adjustment for adult BMI. Normal-weight and overweight were defined by growth references from the Centers for Disease Control and Prevention.RESULTS: We identified four childhood trajectories within the normal-weight spectrum and one trajectory of overweight. Compared to the trajectory with the lowest BMI level, several higher BMI trajectories were associated with worse circumference, HDL and glucose homeostasis in adulthood. The highest trajectory was additionally associated with higher total cholesterol and triglycerides. When adjusting for adult BMI, the higher BMI trajectories had lower waist circumference, blood pressure and triglycerides.CONCLUSIONS: Trajectories of BMI within the normal-weight range and in the overweight range are associated with a worse CVD risk profile than in the lowest BMI trajectory, and these associations are modifiable by growth after childhood.",
keywords = "Blood lipids, Blood pressure, Body mass index, Child, Diabetes mellitus, Growth, Obesity, Type 2",
author = "Kim Blond and Julie Aarestrup and Dorte Vistisen and Bjerregaard, {Lise G} and Jensen, {Gorm Boje} and Janne Petersen and Nordestgaard, {B{\o}rge G} and J{\o}rgensen, {Marit E} and Jensen, {Britt Wang} and Baker, {Jennifer L}",
note = "Copyright {\textcopyright} 2020 Elsevier B.V. All rights reserved.",
year = "2020",
month = dec,
doi = "10.1016/j.atherosclerosis.2020.10.011",
language = "English",
volume = "314",
pages = "10--17",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Associations between body mass index trajectories in childhood and cardiovascular risk factors in adulthood

AU - Blond, Kim

AU - Aarestrup, Julie

AU - Vistisen, Dorte

AU - Bjerregaard, Lise G

AU - Jensen, Gorm Boje

AU - Petersen, Janne

AU - Nordestgaard, Børge G

AU - Jørgensen, Marit E

AU - Jensen, Britt Wang

AU - Baker, Jennifer L

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - BACKGROUND AND AIMS: Children with a growth trajectory of overweight have higher levels of cardiovascular disease (CVD) risk factors than children with a normal-weight trajectory. However, less is known about how trajectories of body mass index (BMI) across the rest of the BMI spectrum relate to CVD risk factors and whether adult BMI affects these associations. Our aim was to examine associations between childhood BMI trajectories and adult CVD risk factors.METHODS: We included 2466 individuals with childhood weights and heights (ages 6-14) from the Copenhagen School Health Records Register and adult CVD risk factors (ages 20-81) from the Copenhagen City Heart Study. Associations between childhood BMI trajectories identified by latent class modelling and CVD risk factors were examined using generalized linear regression analyses with and without adjustment for adult BMI. Normal-weight and overweight were defined by growth references from the Centers for Disease Control and Prevention.RESULTS: We identified four childhood trajectories within the normal-weight spectrum and one trajectory of overweight. Compared to the trajectory with the lowest BMI level, several higher BMI trajectories were associated with worse circumference, HDL and glucose homeostasis in adulthood. The highest trajectory was additionally associated with higher total cholesterol and triglycerides. When adjusting for adult BMI, the higher BMI trajectories had lower waist circumference, blood pressure and triglycerides.CONCLUSIONS: Trajectories of BMI within the normal-weight range and in the overweight range are associated with a worse CVD risk profile than in the lowest BMI trajectory, and these associations are modifiable by growth after childhood.

AB - BACKGROUND AND AIMS: Children with a growth trajectory of overweight have higher levels of cardiovascular disease (CVD) risk factors than children with a normal-weight trajectory. However, less is known about how trajectories of body mass index (BMI) across the rest of the BMI spectrum relate to CVD risk factors and whether adult BMI affects these associations. Our aim was to examine associations between childhood BMI trajectories and adult CVD risk factors.METHODS: We included 2466 individuals with childhood weights and heights (ages 6-14) from the Copenhagen School Health Records Register and adult CVD risk factors (ages 20-81) from the Copenhagen City Heart Study. Associations between childhood BMI trajectories identified by latent class modelling and CVD risk factors were examined using generalized linear regression analyses with and without adjustment for adult BMI. Normal-weight and overweight were defined by growth references from the Centers for Disease Control and Prevention.RESULTS: We identified four childhood trajectories within the normal-weight spectrum and one trajectory of overweight. Compared to the trajectory with the lowest BMI level, several higher BMI trajectories were associated with worse circumference, HDL and glucose homeostasis in adulthood. The highest trajectory was additionally associated with higher total cholesterol and triglycerides. When adjusting for adult BMI, the higher BMI trajectories had lower waist circumference, blood pressure and triglycerides.CONCLUSIONS: Trajectories of BMI within the normal-weight range and in the overweight range are associated with a worse CVD risk profile than in the lowest BMI trajectory, and these associations are modifiable by growth after childhood.

KW - Blood lipids

KW - Blood pressure

KW - Body mass index

KW - Child

KW - Diabetes mellitus

KW - Growth

KW - Obesity

KW - Type 2

UR - http://www.scopus.com/inward/record.url?scp=85093925392&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2020.10.011

DO - 10.1016/j.atherosclerosis.2020.10.011

M3 - Journal article

C2 - 33129081

VL - 314

SP - 10

EP - 17

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -

ID: 61261002