Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

Noa Carrera; Manuel Arrojo; Julio Sanjuán; Ramón Ramos-Ríos; Eduardo Paz; Jose J Suárez-Rama; Mario Páramo; Santiago Agra; Julio Brenlla; Silvia Martínez; Olga Rivero; David A Collier; Aarno Palotie; Sven Cichon; Markus M Nöthen; Marcella Rietschel; Dan Rujescu; Hreinn Stefansson; Stacy Steinberg; Engilbert Sigurdsson; David St Clair; Sarah Tosato; Thomas Werge; Kari Stefansson; Jose Carlos González; Joaquín Valero; Alfonso Gutiérrez-Zotes; Antonio Labad; Lourdes Martorell; Elisabet Vilella; Ángel Carracedo; Javier Costas

doi:10.1016/j.biopsych.2011.09.032

Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

Noa Carrera, Manuel Arrojo, Julio Sanjuán, Ramón Ramos-Ríos, Eduardo Paz, Jose J Suárez-Rama, Mario Páramo, Santiago Agra, Julio Brenlla, Silvia Martínez, Olga Rivero, David A Collier, Aarno Palotie, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Dan Rujescu, Hreinn Stefansson, Stacy Steinberg, Engilbert SigurdssonDavid St Clair, Sarah Tosato, Thomas Werge, Kari Stefansson, Jose Carlos González, Joaquín Valero, Alfonso Gutiérrez-Zotes, Antonio Labad, Lourdes Martorell, Elisabet Vilella, Ángel Carracedo, Javier Costas

69 Citationer (Scopus)

Abstrakt

Genome-wide association studies using several hundred thousand anonymous markers present limited statistical power. Alternatively, association studies restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the advantage of strongly reducing the multiple testing problem, while increasing the probability of testing functional single nucleotide polymorphisms (SNPs).

Originalsprog	Engelsk
Tidsskrift	Biological Psychiatry
Vol/bind	71
Udgave nummer	2
Sider (fra-til)	169-77
Antal sider	9
ISSN	0006-3223
DOI	https://doi.org/10.1016/j.biopsych.2011.09.032
Status	Udgivet - 2012

Adgang til dokumentet

10.1016/j.biopsych.2011.09.032

Citationsformater

Carrera, N., Arrojo, M., Sanjuán, J., Ramos-Ríos, R., Paz, E., Suárez-Rama, J. J., Páramo, M., Agra, S., Brenlla, J., Martínez, S., Rivero, O., Collier, D. A., Palotie, A., Cichon, S., Nöthen, M. M., Rietschel, M., Rujescu, D., Stefansson, H., Steinberg, S., ... Costas, J. (2012). Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. Biological Psychiatry, 71(2), 169-77. https://doi.org/10.1016/j.biopsych.2011.09.032

Carrera, N, Arrojo, M, Sanjuán, J, Ramos-Ríos, R, Paz, E, Suárez-Rama, JJ, Páramo, M, Agra, S, Brenlla, J, Martínez, S, Rivero, O, Collier, DA, Palotie, A, Cichon, S, Nöthen, MM, Rietschel, M, Rujescu, D, Stefansson, H, Steinberg, S, Sigurdsson, E, St Clair, D, Tosato, S, Werge, T, Stefansson, K, González, JC, Valero, J, Gutiérrez-Zotes, A, Labad, A, Martorell, L, Vilella, E, Carracedo, Á & Costas, J 2012, 'Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia', Biological Psychiatry, bind 71, nr. 2, s. 169-77. https://doi.org/10.1016/j.biopsych.2011.09.032

@article{03e77b7fadb74d96aee1d80687b1fb4f,

title = "Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia",

abstract = "Genome-wide association studies using several hundred thousand anonymous markers present limited statistical power. Alternatively, association studies restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the advantage of strongly reducing the multiple testing problem, while increasing the probability of testing functional single nucleotide polymorphisms (SNPs).",

author = "Noa Carrera and Manuel Arrojo and Julio Sanju{\'a}n and Ram{\'o}n Ramos-R{\'i}os and Eduardo Paz and Su{\'a}rez-Rama, {Jose J} and Mario P{\'a}ramo and Santiago Agra and Julio Brenlla and Silvia Mart{\'i}nez and Olga Rivero and Collier, {David A} and Aarno Palotie and Sven Cichon and N{\"o}then, {Markus M} and Marcella Rietschel and Dan Rujescu and Hreinn Stefansson and Stacy Steinberg and Engilbert Sigurdsson and {St Clair}, David and Sarah Tosato and Thomas Werge and Kari Stefansson and Gonz{\'a}lez, {Jose Carlos} and Joaqu{\'i}n Valero and Alfonso Guti{\'e}rrez-Zotes and Antonio Labad and Lourdes Martorell and Elisabet Vilella and {\'A}ngel Carracedo and Javier Costas",

year = "2012",

doi = "10.1016/j.biopsych.2011.09.032",

language = "English",

volume = "71",

pages = "169--77",

journal = "Biological Psychiatry",

issn = "0006-3223",

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TY - JOUR

T1 - Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

AU - Carrera, Noa

AU - Arrojo, Manuel

AU - Sanjuán, Julio

AU - Ramos-Ríos, Ramón

AU - Paz, Eduardo

AU - Suárez-Rama, Jose J

AU - Páramo, Mario

AU - Agra, Santiago

AU - Brenlla, Julio

AU - Martínez, Silvia

AU - Rivero, Olga

AU - Collier, David A

AU - Palotie, Aarno

AU - Cichon, Sven

AU - Nöthen, Markus M

AU - Rietschel, Marcella

AU - Rujescu, Dan

AU - Stefansson, Hreinn

AU - Steinberg, Stacy

AU - Sigurdsson, Engilbert

AU - St Clair, David

AU - Tosato, Sarah

AU - Werge, Thomas

AU - Stefansson, Kari

AU - González, Jose Carlos

AU - Valero, Joaquín

AU - Gutiérrez-Zotes, Alfonso

AU - Labad, Antonio

AU - Martorell, Lourdes

AU - Vilella, Elisabet

AU - Carracedo, Ángel

AU - Costas, Javier

PY - 2012

Y1 - 2012

N2 - Genome-wide association studies using several hundred thousand anonymous markers present limited statistical power. Alternatively, association studies restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the advantage of strongly reducing the multiple testing problem, while increasing the probability of testing functional single nucleotide polymorphisms (SNPs).

AB - Genome-wide association studies using several hundred thousand anonymous markers present limited statistical power. Alternatively, association studies restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the advantage of strongly reducing the multiple testing problem, while increasing the probability of testing functional single nucleotide polymorphisms (SNPs).

U2 - 10.1016/j.biopsych.2011.09.032

DO - 10.1016/j.biopsych.2011.09.032

M3 - Journal article

C2 - 22078303

VL - 71

SP - 169

EP - 177

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 2

ER -

Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

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