Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer

Martin Blomberg Jensen; H Leffers; J H Petersen; G Daugaard; N E Skakkebaek; E Rajpert-De Meyts

doi:10.1093/annonc/mdn407

Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer

Martin Blomberg Jensen, H Leffers, J H Petersen, G Daugaard, N E Skakkebaek, E Rajpert-De Meyts

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23 Citationer (Scopus)

Abstract

A possible association between the polymorphic CAG repeat in the DNA polymerase gamma (POLG) gene and the risk of testicular germ-cell tumours (TGCT) was investigated in this study. The hypothesis was prompted by an earlier preliminary study proposing an association of the absence of the common 10-CAG-long POLG allele with testicular cancer as well as previously reported in some European populations' association with male subfertility, which is a condition carrying an increased risk of TGCT.

Originalsprog	Engelsk
Tidsskrift	Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
Vol/bind	19
Udgave nummer	11
Sider (fra-til)	1910-4
Antal sider	5
ISSN	0923-7534
DOI	https://doi.org/10.1093/annonc/mdn407
Status	Udgivet - nov. 2008

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10.1093/annonc/mdn407

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Jensen, M. B., Leffers, H., Petersen, J. H., Daugaard, G., Skakkebaek, N. E., & Rajpert-De Meyts, E. (2008). Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 19(11), 1910-4. https://doi.org/10.1093/annonc/mdn407

Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer. / Jensen, Martin Blomberg ; Leffers, H ; Petersen, J H et al.

I: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Bind 19, Nr. 11, 11.2008, s. 1910-4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Jensen, MB , Leffers, H , Petersen, JH , Daugaard, G , Skakkebaek, NE & Rajpert-De Meyts, E 2008, 'Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer', Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, bind 19, nr. 11, s. 1910-4. https://doi.org/10.1093/annonc/mdn407

Jensen MB , Leffers H , Petersen JH , Daugaard G , Skakkebaek NE , Rajpert-De Meyts E. Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2008 nov.;19(11):1910-4. https://doi.org/10.1093/annonc/mdn407

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abstract = "A possible association between the polymorphic CAG repeat in the DNA polymerase gamma (POLG) gene and the risk of testicular germ-cell tumours (TGCT) was investigated in this study. The hypothesis was prompted by an earlier preliminary study proposing an association of the absence of the common 10-CAG-long POLG allele with testicular cancer as well as previously reported in some European populations' association with male subfertility, which is a condition carrying an increased risk of TGCT.",

keywords = "Adult, Alleles, Case-Control Studies, DNA-Directed DNA Polymerase, Genotype, Humans, Male, Neoplasm Staging, Neoplasms, Germ Cell and Embryonal, Polymorphism, Genetic, Testicular Neoplasms, Trinucleotide Repeats",

author = "Jensen, {Martin Blomberg} and H Leffers and Petersen, {J H} and G Daugaard and Skakkebaek, {N E} and {Rajpert-De Meyts}, E",

year = "2008",

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AU - Skakkebaek, N E

AU - Rajpert-De Meyts, E

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AB - A possible association between the polymorphic CAG repeat in the DNA polymerase gamma (POLG) gene and the risk of testicular germ-cell tumours (TGCT) was investigated in this study. The hypothesis was prompted by an earlier preliminary study proposing an association of the absence of the common 10-CAG-long POLG allele with testicular cancer as well as previously reported in some European populations' association with male subfertility, which is a condition carrying an increased risk of TGCT.

KW - Adult

KW - Alleles

KW - Case-Control Studies

KW - DNA-Directed DNA Polymerase

KW - Genotype

KW - Humans

KW - Male

KW - Neoplasm Staging

KW - Neoplasms, Germ Cell and Embryonal

KW - Polymorphism, Genetic

KW - Testicular Neoplasms

KW - Trinucleotide Repeats

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DO - 10.1093/annonc/mdn407

M3 - Journal article

C2 - 18632724

VL - 19

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JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 11

ER -

Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer

Abstract

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